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Dominguez MV, Bastos EP, Silva SD, et al. Metodos de investigacion molecular en la deteccion de mutaciones germinativas en cancer colorrectal hereditario. [Molecular research methods in the detection of germinal mutations in hereditary colorectal cancer]. Rev Gastroenterol Peru. 2009;29(3):247-53
Dominguez, M. V., Bastos, E. P., Silva, S. D., & Rossi, B. M. (2009). Metodos de investigacion molecular en la deteccion de mutaciones germinativas en cancer colorrectal hereditario. [Molecular research methods in the detection of germinal mutations in hereditary colorectal cancer]. Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru, 29(3), 247-53.
Dominguez, M V, et al. "Metodos de investigacion molecular en la deteccion de mutaciones germinativas en cancer colorrectal hereditario." [Molecular research methods in the detection of germinal mutations in hereditary colorectal cancer]. Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru vol. 29,3 (2009): 247-53.
Dominguez MV, Bastos EP, Silva SD, Rossi BM. Metodos de investigacion molecular en la deteccion de mutaciones germinativas en cancer colorrectal hereditario. [Molecular research methods in the detection of germinal mutations in hereditary colorectal cancer]. Rev Gastroenterol Peru. 2009 Jul-Sep;29(3):247-53. Spanish. PMID: 19898597.
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Rev Gastroenterol Peru. 2009 Jul-Sep;29(3):247-53.

[Molecular research methods in the detection of germinal mutations in hereditary colorectal cancer].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru

[Article in Spanish]
M V Dominguez, E P Bastos, S D Silva, B M Rossi

Affiliations

  1. Laboratorório de Genómica y Biologia Molecular del Centro de Investigaciones del Hospital AC Camargo, São Paulo 01509-010, Brazil. [email protected]

PMID: 19898597

Abstract

Colorectal cancer (CRC) is one of the main causes of death in South American countries. The hereditary forms of CRC are, familial adenomatous (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch Syndrome (LS), which is the most common form. The detection of mutations in the DNA repair genes (MMR) and in the APC genes enables the development of prevention strategies. Some of these methods for molecular diagnosis are applied in research and the detection of mutations of these genes, such as the partial thromboplastin time test (PTT), the single strand conformational polymorphism test (SSCP), the Denaturing High Performance Liquid Chromatography test (DHPLC) and the Polymerase Chain Reaction (PCR) in real time (qPCR).

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