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Morgan C, Hsu KC, Rifkind RA, et al. THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : II. THE INTERIOR OF THE CELL. J Exp Med. 1961;114(5):833-6doi: 10.1084/jem.114.5.833.
Morgan, C., Hsu, K. C., Rifkind, R. A., Knox, A. W., & Rose, H. M. (1961). THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : II. THE INTERIOR OF THE CELL. The Journal of experimental medicine, 114(5), 833-6. https://doi.org/10.1084/jem.114.5.833
Morgan, C, et al. "THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : II. THE INTERIOR OF THE CELL." The Journal of experimental medicine vol. 114,5 (1961): 833-6. doi: https://doi.org/10.1084/jem.114.5.833
Morgan C, Hsu KC, Rifkind RA, Knox AW, Rose HM. THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : II. THE INTERIOR OF THE CELL. J Exp Med. 1961 Oct 31;114(5):833-6. doi: 10.1084/jem.114.5.833. PMID: 19867208; PMCID: PMC2180384.
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J Exp Med. 1961 Oct 31;114(5):833-6. doi: 10.1084/jem.114.5.833.

THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : II. THE INTERIOR OF THE CELL.

The Journal of experimental medicine

C Morgan, K C Hsu, R A Rifkind, A W Knox, H M Rose

Affiliations

  1. Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York.

PMID: 19867208 PMCID: PMC2180384 DOI: 10.1084/jem.114.5.833

Abstract

Freezing of the chorioallantoic membrane after brief fixation in formalin preserves antigenicity of cellular components and allows penetration of ferritin-conjugated antibody. Dense aggregates of viral antigen, presumed to be of the soluble type, were found in the nuclei of cells infected with influenza virus. Intracytoplasmic antigen, on the other hand, was widely dispersed. The experimental observations are consistent with the hypothesis that soluble antigen diffuses into the cytoplasm through intact nuclear membranes. Nucleoli do not appear to be the sites of antigen synthesis.

References

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