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Rifkind RA, Osserman EF, Hsu KC, et al. THE INTRACELLULAR DISTRIBUTION OF GAMMA GLOBULIN IN A MOUSE PLASMA CELL TUMOR (X5563) AS REVEALED BY FLUORESCENCE AND ELECTRON MICROSCOPY. J Exp Med. 1962;116(4):423-32doi: 10.1084/jem.116.4.423.
Rifkind, R. A., Osserman, E. F., Hsu, K. C., & Morgan, C. (1962). THE INTRACELLULAR DISTRIBUTION OF GAMMA GLOBULIN IN A MOUSE PLASMA CELL TUMOR (X5563) AS REVEALED BY FLUORESCENCE AND ELECTRON MICROSCOPY. The Journal of experimental medicine, 116(4), 423-32. https://doi.org/10.1084/jem.116.4.423
Rifkind, R A, et al. "THE INTRACELLULAR DISTRIBUTION OF GAMMA GLOBULIN IN A MOUSE PLASMA CELL TUMOR (X5563) AS REVEALED BY FLUORESCENCE AND ELECTRON MICROSCOPY." The Journal of experimental medicine vol. 116,4 (1962): 423-32. doi: https://doi.org/10.1084/jem.116.4.423
Rifkind RA, Osserman EF, Hsu KC, Morgan C. THE INTRACELLULAR DISTRIBUTION OF GAMMA GLOBULIN IN A MOUSE PLASMA CELL TUMOR (X5563) AS REVEALED BY FLUORESCENCE AND ELECTRON MICROSCOPY. J Exp Med. 1962 Oct 01;116(4):423-32. doi: 10.1084/jem.116.4.423. PMID: 19867216; PMCID: PMC2137627.
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J Exp Med. 1962 Oct 01;116(4):423-32. doi: 10.1084/jem.116.4.423.

THE INTRACELLULAR DISTRIBUTION OF GAMMA GLOBULIN IN A MOUSE PLASMA CELL TUMOR (X5563) AS REVEALED BY FLUORESCENCE AND ELECTRON MICROSCOPY.

The Journal of experimental medicine

R A Rifkind, E F Osserman, K C Hsu, C Morgan

Affiliations

  1. Departments of Medicine and Microbiology, Columbia University, College of Physicians and Surgeons, New York.

PMID: 19867216 PMCID: PMC2137627 DOI: 10.1084/jem.116.4.423

Abstract

Ferritin- and fluorescein-conjugated antibody staining has been applied to a study of a mouse plasma cell tumor. The presence of myeloma globulin within cisternae of the endoplasmic reticulum was observed at a stage of the secretory process when the remainder of the cytoplasm was essentially free of labeled globulin. The distribution of ferritin suggested a functional heterogeneity among units of the endoplasmic reticulum. Apparently, progressive accumulation of globulin results in distension of the endoplasmic reticulum and, occasionally, in the appearance of considerable quantities of this secretory protein in the extracisternal cytoplasmic matrix. Participation of the Golgi apparatus in the packaging and release of small quantitites of globulin seems likely. In addition, however, fragmentation of the peripheral cytoplasm with rupture of distended ergastoplasmic vesicles appeared to be another pathway whereby globulin is secreted.

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