J Exp Med. 1914 Jan 01;19(1):1-19. doi: 10.1084/jem.19.1.1.
The Journal of experimental medicine
C J Wiggers
PMID: 19867744 PMCID: PMC2125144 DOI: 10.1084/jem.19.1.1
Changes in cardiac rhythm are not the only determinants of blood pressure variations in man. They play a part in the variations of systolic and diastolic pressures, the relative importance of which depends on the degree of arhythmia present and on the depth of respiration which, in itself, causes the systolic and diastolic pressures to decrease during inspiration and increase during expiration. No degree of rate variation can be regarded as a type. The cases range from those in which respiration governs the change of pressures entirely through those where more or less complicated mixtures of heart rate and respiratory influences intermingle to those in which extreme cardiac variations alone determine the pressure changes. The emphatic insistence of Henderson and his collaborators that heart rate changes play a more important part than is commonly recognized in man is true in many cases. That, in certain cases, it is the only determining influence may also be admitted, but they are in the minority. The majority show the intervention of a respiratory influence which controls, at least, the variations of systolic pressure. In the light of these results, the doctrine that, in man, an effective venous pressure exists sufficient during all respiratory phases to insure superimposable beats, must be subjected to further reinvestigation.
