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Rivers TM. SKIN INFECTION OF RABBITS WITH HEMOLYTIC STREPTOCOCCI ISOLATED FROM A PATIENT WITH ERYSIPELAS : I. METHOD OF DEMONSTRATING PROTECTIVE ACTION OF IMMUNE SERA. J Exp Med. 1925;41(2):179-84doi: 10.1084/jem.41.2.179.
Rivers, T. M. (1925). SKIN INFECTION OF RABBITS WITH HEMOLYTIC STREPTOCOCCI ISOLATED FROM A PATIENT WITH ERYSIPELAS : I. METHOD OF DEMONSTRATING PROTECTIVE ACTION OF IMMUNE SERA. The Journal of experimental medicine, 41(2), 179-84. https://doi.org/10.1084/jem.41.2.179
Rivers, T M. "SKIN INFECTION OF RABBITS WITH HEMOLYTIC STREPTOCOCCI ISOLATED FROM A PATIENT WITH ERYSIPELAS : I. METHOD OF DEMONSTRATING PROTECTIVE ACTION OF IMMUNE SERA." The Journal of experimental medicine vol. 41,2 (1925): 179-84. doi: https://doi.org/10.1084/jem.41.2.179
Rivers TM. SKIN INFECTION OF RABBITS WITH HEMOLYTIC STREPTOCOCCI ISOLATED FROM A PATIENT WITH ERYSIPELAS : I. METHOD OF DEMONSTRATING PROTECTIVE ACTION OF IMMUNE SERA. J Exp Med. 1925 Jan 31;41(2):179-84. doi: 10.1084/jem.41.2.179. PMID: 19868979; PMCID: PMC2130937.
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J Exp Med. 1925 Jan 31;41(2):179-84. doi: 10.1084/jem.41.2.179.

SKIN INFECTION OF RABBITS WITH HEMOLYTIC STREPTOCOCCI ISOLATED FROM A PATIENT WITH ERYSIPELAS : I. METHOD OF DEMONSTRATING PROTECTIVE ACTION OF IMMUNE SERA.

The Journal of experimental medicine

T M Rivers

Affiliations

  1. Hospital of The Rockefeller Institute for Medical Research.

PMID: 19868979 PMCID: PMC2130937 DOI: 10.1084/jem.41.2.179

Abstract

Cultures of a hemolytic streptococcus isolated from a human case of erysipelas were tested for ability to produce lesions by injecting various amounts intradermally in shaved rabbits. Severe lesions could be developed at will in this way despite the fact that intravenous or intraperitoneal inoculations of large doses of the cultures failed to kill. The lesions were of two sorts, phlegmonous and erysipelas-like. A serum capable of warding off the injurious action of the streptococcus on the skin was procured from animals receiving repeated intracutaneous inoculations of the organism. Normal serum by contrast had no protective effect. By intradermal injections at several points in the same normal rabbit of small quantities of mixtures of equal parts of serum and various dilutions of a suspension of streptococci it proved possible to test sera for the presence of substances protective against the streptococcus.

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