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J Exp Med. 1928 Mar 31;47(4):503-14. doi: 10.1084/jem.47.4.503.

THE USE OF HISTAMINE AS A STANDARD TEST FOR DIMINISHED RESISTANCE IN SUPRARENALECTOMIZED RATS.

The Journal of experimental medicine

J Marmorston-Gottesman, J Gottesman

Affiliations

  1. Division of Laboratories of Montefiore Hospital, New York.

PMID: 19869427 PMCID: PMC2131396 DOI: 10.1084/jem.47.4.503

Abstract

Of all the drugs thus far used in testing the resistance of suprarenalectomized rats, histamine has been found to be the most satisfactory. It is a readily obtainable and comparatively stable drug, producing characteristic symptoms. Its M.L.D. for a given strain of rats can be established within narrow limits, and the difference between the M.L.D. for normal and suprarenalectomized rats is comparatively great (1:20).

References

  1. J Exp Med. 1923 Oct 31;38(5):543-60 - PubMed

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