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Oliver JR, Lund EM. CELLULAR MECHANISMS OF RENAL SECRETION. A STUDY BY THE EXTRAVITAL METHOD : II. THE FUNCTIONAL PHASE OF THE SECRETORY MECHANISM. J Exp Med. 1933;57(3):459-83doi: 10.1084/jem.57.3.459.
Oliver, J. R., & Lund, E. M. (1933). CELLULAR MECHANISMS OF RENAL SECRETION. A STUDY BY THE EXTRAVITAL METHOD : II. THE FUNCTIONAL PHASE OF THE SECRETORY MECHANISM. The Journal of experimental medicine, 57(3), 459-83. https://doi.org/10.1084/jem.57.3.459
Oliver, J R, and Lund, E M. "CELLULAR MECHANISMS OF RENAL SECRETION. A STUDY BY THE EXTRAVITAL METHOD : II. THE FUNCTIONAL PHASE OF THE SECRETORY MECHANISM." The Journal of experimental medicine vol. 57,3 (1933): 459-83. doi: https://doi.org/10.1084/jem.57.3.459
Oliver JR, Lund EM. CELLULAR MECHANISMS OF RENAL SECRETION. A STUDY BY THE EXTRAVITAL METHOD : II. THE FUNCTIONAL PHASE OF THE SECRETORY MECHANISM. J Exp Med. 1933 Feb 28;57(3):459-83. doi: 10.1084/jem.57.3.459. PMID: 19870142; PMCID: PMC2132232.
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J Exp Med. 1933 Feb 28;57(3):459-83. doi: 10.1084/jem.57.3.459.

CELLULAR MECHANISMS OF RENAL SECRETION. A STUDY BY THE EXTRAVITAL METHOD : II. THE FUNCTIONAL PHASE OF THE SECRETORY MECHANISM.

The Journal of experimental medicine

J R Oliver, E M Lund

Affiliations

  1. Department of Pathology of the Long Island College of Medicine, The Hoagland Laboratory, Brooklyn.

PMID: 19870142 PMCID: PMC2132232 DOI: 10.1084/jem.57.3.459

Abstract

1. The elimination of neutral red by the renal epithelium is a composite process, consisting of a direct and an indirect secretion. 2. The mechanism controlling direct secretion is concerned with the permeability of the two cell membranes. These two membranes may be affected independently in the direction of either an increased or decreased permeability, with a corresponding increase or decrease in the elimination of the dye. 3. The mechanism controlling indirect secretion is concerned with the mitochondrial apparatus of the cell. By means of change in the form and constituent substance of its structures, the dye is concentrated within the cell and slowly eliminated. 4. Direct secretion, depending on the condition of sensitive membranes, is easily disturbed. Such disturbances account for the wide variations in the elimination of dye observed in the functioning of abnormal kidneys. Indirect secretion, depending on the simpler factor of the solubility of the dye in the protoplasmic constituents, continues even when the cells are severely damaged.

References

  1. Science. 1931 Aug 14;74(1911):174-5 - PubMed
  2. Science. 1931 Mar 20;73(1890):297-303 - PubMed
  3. J Exp Med. 1931 May 31;53(6):763-84 - PubMed
  4. J Exp Med. 1931 May 31;53(6):785-801 - PubMed

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