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Goodner K, Horsfall FL. THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : IV. THE PROZONE. J Exp Med. 1936;64(3):369-75doi: 10.1084/jem.64.3.369.
Goodner, K., & Horsfall, F. L. (1936). THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : IV. THE PROZONE. The Journal of experimental medicine, 64(3), 369-75. https://doi.org/10.1084/jem.64.3.369
Goodner, K, and Horsfall, F L. "THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : IV. THE PROZONE." The Journal of experimental medicine vol. 64,3 (1936): 369-75. doi: https://doi.org/10.1084/jem.64.3.369
Goodner K, Horsfall FL. THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : IV. THE PROZONE. J Exp Med. 1936 Aug 31;64(3):369-75. doi: 10.1084/jem.64.3.369. PMID: 19870541; PMCID: PMC2133425.
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J Exp Med. 1936 Aug 31;64(3):369-75. doi: 10.1084/jem.64.3.369.

THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : IV. THE PROZONE.

The Journal of experimental medicine

K Goodner, F L Horsfall

Affiliations

  1. Hospital of The Rockefeller Institute for Medical Research.

PMID: 19870541 PMCID: PMC2133425 DOI: 10.1084/jem.64.3.369

Abstract

1. Type I antipneumococcus horse serum, in amounts exceeding a characteristic optimum, fails to protect mice against infection with the homologous type pneumococci. This failure is due to a marked inhibition of the phagocytic mechanism in the earlier stages of the infectious process. On the other hand, antipneumococcus rabbit serum in similar quantities does not inhibit phagocytosis, nor does it block the protection. 2. The experimental evidence suggests that the prozoning action of immune horse serum is due primarily to some characteristic property of the specific antibody and secondarily to an heterologous component of the serum, ineffective in itself but acting through the mediation of the antigen-antibody combination. This secondary factor may be a lipid.

References

  1. J Exp Med. 1935 Aug 31;62(3):359-74 - PubMed
  2. J Exp Med. 1935 Aug 31;62(3):375-91 - PubMed

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