Display options
Cite
Shah SS, Tsang SH, Mahajan VB. Erythropoetin receptor expression in the human diabetic retina. BMC Res Notes. 2009;2:234doi: 10.1186/1756-0500-2-234.
Shah, S. S., Tsang, S. H., & Mahajan, V. B. (2009). Erythropoetin receptor expression in the human diabetic retina. BMC research notes, 2234. https://doi.org/10.1186/1756-0500-2-234
Shah, Shaival S, et al. "Erythropoetin receptor expression in the human diabetic retina." BMC research notes vol. 2 (2009): 234. doi: https://doi.org/10.1186/1756-0500-2-234
Shah SS, Tsang SH, Mahajan VB. Erythropoetin receptor expression in the human diabetic retina. BMC Res Notes. 2009 Nov 25;2:234. doi: 10.1186/1756-0500-2-234. PMID: 19930719; PMCID: PMC2785834.
Copy Download .nbib Format: NLM
Share it on

BMC Res Notes. 2009 Nov 25;2:234. doi: 10.1186/1756-0500-2-234.

Erythropoetin receptor expression in the human diabetic retina.

BMC research notes

Shaival S Shah, Stephen H Tsang, Vinit B Mahajan

Affiliations

  1. Vitreoretinal Service, Department of Ophthalmology and Visual Sciences, The University of Iowa Hospitals & Clinics, 200 Hawkins Drive, USA. [email protected]

PMID: 19930719 PMCID: PMC2785834 DOI: 10.1186/1756-0500-2-234

Abstract

BACKGROUND: Recent evidence suggests erythropoietin (EPO) and the erythropoietin receptor (EPOR) may play a direct role in the pathogenesis of diabetic retinopathy. Better characterization of the EPO-EPOR signaling system in the ischemic retina may offer a new therapeutic modality for ischemic ophthalmic diseases. This study was performed to identify EPOR mRNA expression in the human diabetic eye.

FINDINGS: EPOR antisense RNA probes were validated on human pancreas tissue. In the normal eye, EPOR was expressed in the retinal ganglion cell layer. Minimal expression was observed in the inner and outer nuclear layer. Under conditions of diabetic retinopathy, EPOR expression shifted to photoreceptor cells. Increased expression was also observed in the peripheral retina.

CONCLUSION: EPOR expression may be a biomarker or contribute to disease mechanisms in diabetic retinopathy.

References

  1. Invest Ophthalmol Vis Sci. 1987 Dec;28(12):1888-904 - PubMed
  2. Transplantation. 2003 Apr 27;75(8):1356-60 - PubMed
  3. J Clin Invest. 2008 Feb;118(2):526-33 - PubMed
  4. Annu Rev Pathol. 2008;3:615-43 - PubMed
  5. Am J Kidney Dis. 1995 Jul;26(1):202-8 - PubMed
  6. Nat Med. 2002 Jul;8(7):718-24 - PubMed
  7. Blood. 1991 Feb 1;77(3):419-34 - PubMed
  8. Br J Ophthalmol. 2007 Oct;91(10):1376-8 - PubMed
  9. Invest Ophthalmol Vis Sci. 2008 Feb;49(2):732-42 - PubMed
  10. JAMA. 2007 Aug 22;298(8):902-16 - PubMed
  11. Diabetes Metab Res Rev. 2000 May-Jun;16(3):172-6 - PubMed
  12. Invest Ophthalmol Vis Sci. 2002 Jun;43(6):2021-6 - PubMed
  13. J Clin Epidemiol. 1997 Feb;50(2):153-8 - PubMed
  14. Eye (Lond). 2002 May;16(3):242-60 - PubMed
  15. Diabetes Care. 2008 Jun;31(6):1189-94 - PubMed
  16. FASEB J. 2005 Feb;19(2):249-51 - PubMed
  17. Blood. 2006 Mar 1;107(5):1892-5 - PubMed
  18. N Engl J Med. 1991 May 9;324(19):1339-44 - PubMed
  19. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):849-57 - PubMed
  20. Am J Physiol. 1992 Sep;263(3 Pt 2):F474-81 - PubMed
  21. Curr Eye Res. 2007 Sep;32(9):757-64 - PubMed
  22. Oncologist. 2004;9 Suppl 5:18-30 - PubMed
  23. Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1329-35 - PubMed
  24. Kidney Int Suppl. 2003 Nov;(87):S57-63 - PubMed
  25. J Biochem. 2004 Jan;135(1):33-42 - PubMed
  26. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3974-8 - PubMed
  27. Brain Res. 2004 Sep 24;1021(2):167-72 - PubMed
  28. N Engl J Med. 2005 Aug 25;353(8):782-92 - PubMed
  29. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10659-64 - PubMed
  30. Arch Ophthalmol. 1968 Sep;80(3):332-7 - PubMed

Publication Types

Grant support