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Halvorsen R, Jenner A, Hagelin EM, et al. Phadiatop infant in the diagnosis of atopy in children with allergy-like symptoms. Int J Pediatr. 2009;2009:460737doi: 10.1155/2009/460737.
Halvorsen, R., Jenner, A., Hagelin, E. M., & Borres, M. P. (2009). Phadiatop infant in the diagnosis of atopy in children with allergy-like symptoms. International journal of pediatrics, 2009460737. https://doi.org/10.1155/2009/460737
Halvorsen, Ragnhild, et al. "Phadiatop infant in the diagnosis of atopy in children with allergy-like symptoms." International journal of pediatrics vol. 2009 (2009): 460737. doi: https://doi.org/10.1155/2009/460737
Halvorsen R, Jenner A, Hagelin EM, Borres MP. Phadiatop infant in the diagnosis of atopy in children with allergy-like symptoms. Int J Pediatr. 2009;2009:460737. doi: 10.1155/2009/460737. Epub 2009 Aug 24. PMID: 20041015; PMCID: PMC2778347.
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Int J Pediatr. 2009;2009:460737. doi: 10.1155/2009/460737. Epub 2009 Aug 24.

Phadiatop infant in the diagnosis of atopy in children with allergy-like symptoms.

International journal of pediatrics

Ragnhild Halvorsen, Asa Jenner, Else Marie Hagelin, Magnus P Borres

Affiliations

  1. Voksentoppen Center for Asthma, Allergy and Chronic Lung Diseases, University Hospital, 0791 Oslo, Norway.

PMID: 20041015 PMCID: PMC2778347 DOI: 10.1155/2009/460737

Abstract

Background and Objective. Allergy-like symptoms such as wheezing and eczema are common in young children and an early diagnosis is important to initiate correct management. The objective of this study was to evaluate the diagnostic performance of Phadiatop Infant, an in vitro test for determination of early sensitisation to food and inhalant allergens. Patients and Methods. The study was conducted, retrospectively, using frozen sera from 122 children (median age 2.7 years) admitted to the hospital with suspected allergic symptoms. The doctor's diagnosis atopic/nonatopic was based on routinely used procedures such as clinical evaluation, SPT, total and allergen-specific IgE antibodies. The performance of Phadiatop Infant was evaluated in a blinded manner against this diagnosis. Results. Eighty-four of the 86 children classified as atopic showed a positive Phadiatop Infant test. Thirty-six were classified as nonatopic, 32 of who had a negative test. With a prevalence of atopy of 70% in this population, this gives a sensitivity of 98%, a specificity of 89%, and a positive and negative predictive value of 95% and 94%, respectively. Conclusion. The results from the present study suggest that Phadiatop Infant could be recommended as a complement to the clinical information in the differential diagnosis on IgE-mediated disease in young children with allergy-like symptoms.

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