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Lorsomradee S, Lorsomradee S. The use of a volatile anesthetic regimen protects against acute normovolemic hemodilution induced myocardial depression in patients with coronary artery disease. Asian J Transfus Sci. 2009;3(1):10-3doi: 10.4103/0973-6247.44474.
Lorsomradee, S., & Lorsomradee, S. (2009). The use of a volatile anesthetic regimen protects against acute normovolemic hemodilution induced myocardial depression in patients with coronary artery disease. Asian journal of transfusion science, 3(1), 10-3. https://doi.org/10.4103/0973-6247.44474
Lorsomradee, Sratwadee, and Lorsomradee, Suraphong. "The use of a volatile anesthetic regimen protects against acute normovolemic hemodilution induced myocardial depression in patients with coronary artery disease." Asian journal of transfusion science vol. 3,1 (2009): 10-3. doi: https://doi.org/10.4103/0973-6247.44474
Lorsomradee S, Lorsomradee S. The use of a volatile anesthetic regimen protects against acute normovolemic hemodilution induced myocardial depression in patients with coronary artery disease. Asian J Transfus Sci. 2009 Jan;3(1):10-3. doi: 10.4103/0973-6247.44474. PMID: 20041090; PMCID: PMC2798776.
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Asian J Transfus Sci. 2009 Jan;3(1):10-3. doi: 10.4103/0973-6247.44474.

The use of a volatile anesthetic regimen protects against acute normovolemic hemodilution induced myocardial depression in patients with coronary artery disease.

Asian journal of transfusion science

Sratwadee Lorsomradee, Suraphong Lorsomradee

Affiliations

  1. Department of Anesthesiology, Chiangmai University Hospital, Thailand.

PMID: 20041090 PMCID: PMC2798776 DOI: 10.4103/0973-6247.44474

Abstract

BACKGROUND: Previous studies indicated that acute normovolemic hemodilution (ANH) was associated with a depression of myocardial function in coronary surgery patients with baseline heart rate faster than 90 bpm. It was suggested that this phenomenon could be explained by the occurrence of myocardial ischemia. In the present study, we hypothesized that the cardioprotective properties of a volatile anesthetic regimen might protect against the ANH related myocardial functional impairment.

MATERIALS AND METHODS: Forty elective coronary surgery patients with baseline heart rate faster than 90 bpm were randomly allocated to receive different anesthetic regimens. Group A (n = 20) received midazolam-based anesthesia. Group B (n = 20) received a sevoflurane-based anesthesia. Five-lead electrocardiogram, pulse oximetry, capnography, radial arterial pressure, and Swan Ganz continuous thermodilution cardiac output via right internal jugular vein were monitored. Measurements were obtained before and after ANH. Data were compared using paired t test. All data were expressed as mean +/- SD. Data were considered significant if P < 0.05.

RESULTS: After ANH, systemic vascular resistance was slightly decreased in group A while there was a significant decrease in group B. In group A, cardiac output was slightly decreased from 5.07+/-1.17 l/min to 5.02+/-1.28 l/min after ANH, whereas in group B, cardiac output was significantly increased from 4.84+/-1.21 l/min to 6.02+/-1.28 l/min after ANH.

CONCLUSION: In coronary surgery patients, with baseline heart rate faster than 90 bpm, anesthesia with sevoflurane during ANH was associated with an improvement in myocardial function after ANH, which was not present in patients anesthetized with midazolam.

Keywords: Acute normovolemic hemodilution; coronary artery disease; volatile anesthetic

References

  1. Anesthesiology. 2002 Jul;97(1):33-41 - PubMed
  2. Anesthesiology. 1983 Mar;58(3):277-80 - PubMed
  3. Anesthesiology. 2002 Jul;97(1):4-14 - PubMed
  4. J Appl Physiol (1985). 1999 Aug;87(2):505-9 - PubMed
  5. Anesthesiology. 1997 Mar;86(3):699-709 - PubMed
  6. Anesth Analg. 2006 Aug;103(2):289-96, table of contents - PubMed
  7. Br J Anaesth. 1998 Dec;81(6):905-12 - PubMed
  8. Microvasc Res. 1987 Nov;34(3):290-301 - PubMed
  9. Anesthesiology. 1999 Nov;91(5):1437-46 - PubMed
  10. Anaesthesist. 2001 Aug;50(8):569-79 - PubMed
  11. World J Surg. 1996 Nov-Dec;20(9):1208-17 - PubMed
  12. Anesthesiology. 1997 Aug;87(2):361-70 - PubMed
  13. Anaesthesia. 1995 Nov;50(11):950-3 - PubMed
  14. Br J Anaesth. 2001 Dec;87(6):905-11 - PubMed
  15. J Cardiothorac Vasc Anesth. 2006 Oct;20(5):684-90 - PubMed
  16. Clin Hemorheol Microcirc. 2003;29(3-4):143-8 - PubMed
  17. Anesthesiology. 1996 Oct;85(4):794-807; discussion 27A - PubMed
  18. Br J Anaesth. 1998 Dec;81(6):913-9 - PubMed
  19. Transfus Med Rev. 2002 Jul;16(3):187-99 - PubMed
  20. Transfusion. 2004 Dec;44(12 Suppl):26S-34S - PubMed
  21. Anesth Analg. 1996 Apr;82(4):687-94 - PubMed

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