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Knaus TA, Silver AM, Dominick KC, et al. Age-Related Changes in the Anatomy of Language Regions in Autism Spectrum Disorder. Brain Imaging Behav. 2009;3(1):51-63doi: 10.1007/s11682-008-9048-x.
Knaus, T. A., Silver, A. M., Dominick, K. C., Schuring, M. D., Shaffer, N., Lindgren, K. A., Joseph, R. M., & Tager-Flusberg, H. (2009). Age-Related Changes in the Anatomy of Language Regions in Autism Spectrum Disorder. Brain imaging and behavior, 3(1), 51-63. https://doi.org/10.1007/s11682-008-9048-x
Knaus, Tracey A, et al. "Age-Related Changes in the Anatomy of Language Regions in Autism Spectrum Disorder." Brain imaging and behavior vol. 3,1 (2009): 51-63. doi: https://doi.org/10.1007/s11682-008-9048-x
Knaus TA, Silver AM, Dominick KC, Schuring MD, Shaffer N, Lindgren KA, Joseph RM, Tager-Flusberg H. Age-Related Changes in the Anatomy of Language Regions in Autism Spectrum Disorder. Brain Imaging Behav. 2009 Mar 01;3(1):51-63. doi: 10.1007/s11682-008-9048-x. PMID: 20161060; PMCID: PMC2747745.
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Brain Imaging Behav. 2009 Mar 01;3(1):51-63. doi: 10.1007/s11682-008-9048-x.

Age-Related Changes in the Anatomy of Language Regions in Autism Spectrum Disorder.

Brain imaging and behavior

Tracey A Knaus, Andrew M Silver, Kelli C Dominick, Melanee D Schuring, Nancy Shaffer, Kristen A Lindgren, Robert M Joseph, Helen Tager-Flusberg

Affiliations

  1. Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA.

PMID: 20161060 PMCID: PMC2747745 DOI: 10.1007/s11682-008-9048-x

Abstract

Impairments in language and communication are core features of autism spectrum disorder (ASD). The anatomy of critical language areas has been studied in ASD with inconsistent findings. We used MRI to measure gray matter volume and asymmetry of Heschl's gyrus, planum temporale, pars triangularis, and pars opercularis in 40 children and adolescents with ASD and 40 typically developing individuals, each divided into younger (7-11 years) and older (12-19 years) cohorts. The older group had larger left planum temporale volume and stronger leftward asymmetry than the younger group, regardless of diagnosis. The pars triangularis and opercularis together were larger in ASD than controls. Correlations between frontal language areas with language and symptom severity scores were significant in younger ASD children. Results suggest similar developmental changes in planum temporale anatomy in both groups, but group differences in pars triangularis and opercularis that may be related to language abilities and autism symptom severity.

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