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Swanson B, Sha BE, Keithley JK, et al. Lipoprotein Particle Profiles by Nuclear Magnetic Resonance Spectroscopy in Medically-Underserved HIV-Infected Persons. J Clin Lipidol. 2009;3(6):379-384doi: 10.1016/j.jacl.2009.10.005.
Swanson, B., Sha, B. E., Keithley, J. K., Fogg, L., Nerad, J., Novak, R., & Adeyemi, O. (2009). Lipoprotein Particle Profiles by Nuclear Magnetic Resonance Spectroscopy in Medically-Underserved HIV-Infected Persons. Journal of clinical lipidology, 3(6), 379-384. https://doi.org/10.1016/j.jacl.2009.10.005
Swanson, Barbara, et al. "Lipoprotein Particle Profiles by Nuclear Magnetic Resonance Spectroscopy in Medically-Underserved HIV-Infected Persons." Journal of clinical lipidology vol. 3,6 (2009): 379-384. doi: https://doi.org/10.1016/j.jacl.2009.10.005
Swanson B, Sha BE, Keithley JK, Fogg L, Nerad J, Novak R, Adeyemi O. Lipoprotein Particle Profiles by Nuclear Magnetic Resonance Spectroscopy in Medically-Underserved HIV-Infected Persons. J Clin Lipidol. 2009 Dec 01;3(6):379-384. doi: 10.1016/j.jacl.2009.10.005. PMID: 20161509; PMCID: PMC2797322.
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J Clin Lipidol. 2009 Dec 01;3(6):379-384. doi: 10.1016/j.jacl.2009.10.005.

Lipoprotein Particle Profiles by Nuclear Magnetic Resonance Spectroscopy in Medically-Underserved HIV-Infected Persons.

Journal of clinical lipidology

Barbara Swanson, Beverly E Sha, Joyce K Keithley, Louis Fogg, Judith Nerad, Richard Novak, Oluwatoyin Adeyemi

Affiliations

  1. Rush University College of Nursing, Chicago, Illinois.

PMID: 20161509 PMCID: PMC2797322 DOI: 10.1016/j.jacl.2009.10.005

Abstract

BACKGROUND: HIV infection is associated with dyslipidemia and increased risk for cardiovascular events. Few studies have described lipid status in medically-underserved, HIV-infected ethnic minorities, a group that is characterized by health disparities. OBJECTIVE: The objective was to characterize the lipid profile of a medically-underserved, largely ethnic minority sample of HIV-infected persons using standard lipid panels and nuclear magnetic resonance (NMR) -derived lipoprotein particle profiles. METHODS: Participants were recruited from a randomized controlled trial of a dietary supplement to manage HIV-related dyslipidemia (N=132). At the initial screening visit, sociodemographic, clinical, and behavioral data were collected, and fasting peripheral venous blood specimens were obtained and lipid status was analyzed using the standard lipid panel and the NMR-derived lipoprotein particle profile. RESULTS: Using NMR-derived LDL particle cutoffs, a higher percentage of participants was outside the target range (50%) than when standard LDL cholesterol NCEP cutoffs were used (24%). Antiretroviral therapy, especially protease inhibitor-containing regimens, was associated with higher LDL particle concentration. CONCLUSION: Substantial numbers of medically-underserved, asymptomatic HIV-infected minorities may be at increased risk for CHD based on NMR-derived lipoprotein values.

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