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Beutler JA. Natural Products as a Foundation for Drug Discovery. Curr Protoc Pharmacol. 2009;46:9.11.1-9.11.21doi: 10.1002/0471141755.ph0911s46.
Beutler, J. A. (2009). Natural Products as a Foundation for Drug Discovery. Current protocols in pharmacology, 469.11.1-9.11.21. https://doi.org/10.1002/0471141755.ph0911s46
Beutler, John A. "Natural Products as a Foundation for Drug Discovery." Current protocols in pharmacology vol. 46 (2009): 9.11.1-9.11.21. doi: https://doi.org/10.1002/0471141755.ph0911s46
Beutler JA. Natural Products as a Foundation for Drug Discovery. Curr Protoc Pharmacol. 2009 Sep 01;46:9.11.1-9.11.21. doi: 10.1002/0471141755.ph0911s46. PMID: 20161632; PMCID: PMC2813068.
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Curr Protoc Pharmacol. 2009 Sep 01;46:9.11.1-9.11.21. doi: 10.1002/0471141755.ph0911s46.

Natural Products as a Foundation for Drug Discovery.

Current protocols in pharmacology

John A Beutler

Affiliations

  1. Molecular Targets Development Program Center for Cancer Research National Cancer Institute Frederick, MD 21702 USA [email protected] 301-846-1942 (ph.) 301-846-6177 (fax).

PMID: 20161632 PMCID: PMC2813068 DOI: 10.1002/0471141755.ph0911s46

Abstract

Natural products have contributed to the development of many drugs for diverse indications. While most U.S. pharmaceutical companies have reduced or eliminated their in-house natural product groups, new paradigms and new enterprises have evolved to carry on a role for natural products in the pharmaceutical industry. Many of the reasons for the decline in popularity of natural products are being addressed by the development of new techniques for screening and production. This overview aims to inform pharmacologists of current strategies and techniques that make natural products a viable strategic choice for inclusion in drug discovery programs.

References

  1. J Ethnopharmacol. 2005 Aug 22;100(1-2):72-9 - PubMed
  2. J Med Chem. 1965 Jan;8:1-10 - PubMed
  3. J Nat Prod. 2007 Mar;70(3):461-77 - PubMed
  4. Nat Prod Rep. 2004 Feb;21(1):1-49 - PubMed
  5. J Nat Prod. 2002 Feb;65(2):221-44 - PubMed
  6. J Nat Prod. 1995 Jul;58(7):1039-46 - PubMed
  7. Am J Gastroenterol. 2002 Oct;97(10):2585-8 - PubMed
  8. Chem Biol. 2004 Nov;11(11):1543-52 - PubMed
  9. Science. 2003 Oct 24;302(5645):613-8 - PubMed
  10. Prog Mol Subcell Biol. 2006;43:261-75 - PubMed
  11. Anal Bioanal Chem. 2007 Nov;389(5):1341-63 - PubMed
  12. Phytomedicine. 1996 Nov;3(3):281-5 - PubMed
  13. Experientia. 1985 Jan 15;41(1):70-1 - PubMed
  14. Science. 1993 Apr 9;260(5105):214-6 - PubMed
  15. Bull World Health Organ. 2006 May;84(5):345 - PubMed
  16. J Med Chem. 1993 May 28;36(11):1674-7 - PubMed
  17. Biomol Eng. 2003 Jul;20(4-6):441-58 - PubMed
  18. Am J Gastroenterol. 1999 Nov;94(11):3267-73 - PubMed
  19. Org Lett. 2005 May 12;7(10):1995-8 - PubMed
  20. Biochem Pharmacol. 2007 Oct 15;74(8):1092-101 - PubMed
  21. J Nat Prod. 2001 Jun;64(6):827-8 - PubMed
  22. J Nat Prod. 2005 Oct;68(10):1556-75 - PubMed
  23. J Nat Prod. 2008 Sep;71(9):1595-9 - PubMed
  24. J Endocrinol. 2006 Oct;191(1):1-8 - PubMed
  25. Org Lett. 2001 Dec 27;3(26):4239-42 - PubMed
  26. Curr Opin Investig Drugs. 2007 Dec;8(12):1057-66 - PubMed
  27. Nat New Biol. 1972 Dec 13;240(102):219-20 - PubMed
  28. Org Lett. 2001 May 31;3(11):1649-52 - PubMed
  29. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8045-50 - PubMed
  30. Basic Life Sci. 1992;59:693-8 - PubMed
  31. Science. 1992 Oct 16;258(5081):447-51 - PubMed
  32. J Med Chem. 2008 May 8;51(9):2589-99 - PubMed
  33. N Engl J Med. 2004 Aug 5;351(6):523-6 - PubMed
  34. Bioorg Med Chem Lett. 2007 Feb 15;17(4):1003-7 - PubMed
  35. J Transl Med. 2008 Mar 18;6:14 - PubMed
  36. Science. 1991 May 3;252(5006):675-9 - PubMed
  37. Prog Biochem Pharmacol. 1976;11:18-27 - PubMed
  38. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8885-90 - PubMed
  39. Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26 - PubMed
  40. Mol Pharm. 2008 Mar-Apr;5(2):212-25 - PubMed
  41. J Antibiot (Tokyo). 2006 Sep;59(9):533-42 - PubMed
  42. Nat Prod Rep. 2008 Aug;25(4):662-95 - PubMed
  43. J Am Chem Soc. 2008 May 28;130(21):6658-9 - PubMed
  44. Comb Chem High Throughput Screen. 2005 Sep;8(6):489-98 - PubMed
  45. J Nat Prod. 1993 Jul;56(7):1123-9 - PubMed
  46. Chem Biol. 2007 Oct;14(10):1098-104 - PubMed
  47. Drug Discov Today Technol. 2005 Autumn;2(3):281-6 - PubMed
  48. J Ethnopharmacol. 2004 Aug;93(2-3):351-7 - PubMed
  49. Mol Interv. 2008 Dec;8(6):284-93 - PubMed
  50. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20 - PubMed
  51. Molecules. 2008 Jun 20;13(6):1406-26 - PubMed
  52. Acta Chem Scand. 1972;26(3):1298-9 - PubMed
  53. Nat Prod Rep. 2001 Dec;18(6):641-9 - PubMed
  54. Nat Prod Rep. 2008 Jun;25(3):475-516 - PubMed
  55. J Am Chem Soc. 1971 May 5;93(9):2325-7 - PubMed
  56. Bioorg Med Chem Lett. 2000 May 15;10(10):1029-32 - PubMed
  57. Antiviral Res. 1994 Dec;25(3-4):185-92 - PubMed
  58. J Med Chem. 1991 Nov;34(11):3339-40 - PubMed
  59. J Nat Prod. 1991 Sep-Oct;54(5):1265-70 - PubMed
  60. J Natl Cancer Inst. 1997 Oct 15;89(20):1505-15 - PubMed
  61. J Biotechnol. 1999 Apr 30;70(1-3):15-25 - PubMed
  62. Phytomedicine. 2007;14 Suppl 6:2-4 - PubMed
  63. J Chem Ecol. 2003 Dec;29(12):2781-6 - PubMed
  64. J Nat Prod. 1990 Jul-Aug;53(4):867-74 - PubMed
  65. Molecules. 2008 Jun 19;13(6):1372-83 - PubMed
  66. Antiviral Res. 1993 Feb;20(2):145-54 - PubMed
  67. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14002-7 - PubMed
  68. Mol Pharmacol. 2006 Dec;70(6):1866-75 - PubMed
  69. Anticancer Drug Des. 2000 Apr;15(2):79-98 - PubMed
  70. J Natl Cancer Inst. 1989 Jul 19;81(14):1088-92 - PubMed
  71. Life Sci. 2004 Sep 17;75(18):2233-44 - PubMed
  72. Rev Infect Dis. 1980 Jan-Feb;2(1):129-39 - PubMed
  73. Experientia. 1969 Mar 15;25(3):225-40 - PubMed
  74. Anal Chem. 2002 Aug 15;74(16):3963-71 - PubMed
  75. Drug Discov Today. 2001 Aug 15;6(16):840-847 - PubMed
  76. Cancer Res. 1992 Jul 15;52(14):3892-900 - PubMed
  77. Brain Res. 1985 Mar 18;330(1):135-40 - PubMed
  78. J Nat Prod. 1998 Oct;61(10):1252-6 - PubMed
  79. Science. 1998 Jul 17;281(5375):428-31 - PubMed
  80. Nature. 1984 Apr 19-25;308(5961):693-8 - PubMed
  81. Science. 1997 Jan 17;275(5298):343-9 - PubMed
  82. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4587-94 - PubMed
  83. J Comb Chem. 2002 Jan-Feb;4(1):56-72 - PubMed
  84. Mol Pharmacol. 1994 Apr;45(4):563-9 - PubMed
  85. Altern Med Rev. 2001 Dec;6(6):567-79 - PubMed
  86. Clin Toxicol. 1975;8(2):149-78 - PubMed
  87. Mol Interv. 2007 Feb;7(1):17-25 - PubMed

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