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Sepp D, Esposito L, Zepper P, et al. Surface expression of CXCR4 on circulating CD133progenitor cells is associated with plaque instability in subjects with carotid artery stenosis. J Angiogenes Res. 2009;1:10doi: 10.1186/2040-2384-1-10.
Sepp, D., Esposito, L., Zepper, P., Ott, I., Feurer, R., Sadikovic, S., Hemmer, B., & Poppert, H. (2009). Surface expression of CXCR4 on circulating CD133progenitor cells is associated with plaque instability in subjects with carotid artery stenosis. Journal of angiogenesis research, 110. https://doi.org/10.1186/2040-2384-1-10
Sepp, Dominik, et al. "Surface expression of CXCR4 on circulating CD133progenitor cells is associated with plaque instability in subjects with carotid artery stenosis." Journal of angiogenesis research vol. 1 (2009): 10. doi: https://doi.org/10.1186/2040-2384-1-10
Sepp D, Esposito L, Zepper P, Ott I, Feurer R, Sadikovic S, Hemmer B, Poppert H. Surface expression of CXCR4 on circulating CD133progenitor cells is associated with plaque instability in subjects with carotid artery stenosis. J Angiogenes Res. 2009 Dec 27;1:10. doi: 10.1186/2040-2384-1-10. PMID: 20072672; PMCID: PMC2806248.
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J Angiogenes Res. 2009 Dec 27;1:10. doi: 10.1186/2040-2384-1-10.

Surface expression of CXCR4 on circulating CD133progenitor cells is associated with plaque instability in subjects with carotid artery stenosis.

Journal of angiogenesis research

Dominik Sepp, Lorena Esposito, Peter Zepper, Ilka Ott, Regina Feurer, Suwad Sadikovic, Bernhard Hemmer, Holger Poppert

Affiliations

  1. Department of Neurology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Germany.
  2. Department of Cardiology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Germany.

PMID: 20072672 PMCID: PMC2806248 DOI: 10.1186/2040-2384-1-10

Abstract

BACKGROUND: Circulating progenitor cells (PCs) are considered to contribute to the remodeling of atherosclerotic plaques. Their surface receptor CXCR4 plays an important role in the recruitment of PCs to their target. This study compares the mobilization of PCs and their functional characteristics in asymptomatic subjects with stable and with unstable carotid plaques. This could provide insight into plaque remodeling and help to develop biomarkers for plaque stability.

METHODS: In 31 subjects with asymptomatic carotid artery stenosis we analyzed the number of CD133+ PCs, VEGFR2+CD34+ PCs and the surface expression of CXCR4 on CD133+ PCs by flow cytometry. Subjects underwent bilateral carotid MRI in a 1.5-T scanner in order to allow the categorization of plaques, following the modified criteria of the American Heart Association.

RESULTS: The number of CD133+ PCs and VEGFR2+CD34+ PCs showed no significant difference between subjects with stable and unstable carotid plaques. The expression of CXCR4 on CD133+ PCs was higher in subjects with unstable plaques than in subjects with stable plaques (p = 0.009).

CONCLUSIONS: This study demonstrates an association between functional characteristics of circulating CD133+ PCs and plaque stability in subjects with asymptomatic carotid artery stenosis. The higher expression of CXCR4 on CD133+ PCs suggests a difference in the recruitment of PCs to the injured tissue in subjects with unstable plaques and subjects with stable plaques. As surface expression of CXCR4 on CD133+ PCs differs in subjects with unstable and with stable plaques, CXCR4 is a promising candidate for a serological biomarker for plaque stability.

References

  1. Blood. 2000 Feb 1;95(3):952-8 - PubMed
  2. Circ Res. 2001 Jul 6;89(1):E1-7 - PubMed
  3. Circulation. 2000 Aug 29;102(9):959-64 - PubMed
  4. Circulation. 2004 Oct 5;110(14):2032-8 - PubMed
  5. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4736-41 - PubMed
  6. Circulation. 2003 Nov 18;108(20):2511-6 - PubMed
  7. Circulation. 2001 Oct 23;104(17):2051-6 - PubMed
  8. J Vasc Surg. 1996 May;23(5):755-65; discussion 765-6 - PubMed
  9. Circulation. 1994 May;89(5):2462-78 - PubMed
  10. Stroke. 2005 Jul;36(7):1400-4 - PubMed
  11. Nat Med. 2004 Aug;10(8):858-64 - PubMed
  12. Blood. 2001 Jun 1;97(11):3354-60 - PubMed
  13. Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2054-61 - PubMed
  14. JAMA. 1995 May 10;273(18):1421-8 - PubMed
  15. Nat Med. 1999 Apr;5(4):434-8 - PubMed
  16. Cytometry. 1992;13(2):204-8 - PubMed
  17. Br J Surg. 2001 Jul;88(7):945-50 - PubMed
  18. N Engl J Med. 2003 Feb 13;348(7):593-600 - PubMed
  19. Circulation. 2001 Jun 12;103(23):2776-9 - PubMed
  20. Europace. 2008 Apr;10(4):444-9 - PubMed
  21. Lancet. 2003 Aug 30;362(9385):697-703 - PubMed
  22. Atherosclerosis. 2007 Mar;191(1):115-20 - PubMed
  23. J Clin Invest. 2000 Jun;105(11):1527-36 - PubMed
  24. Circulation. 1992 Dec;86(6 Suppl):III30-42 - PubMed
  25. J Nucl Cardiol. 2008 Mar-Apr;15(2):266-75 - PubMed
  26. Circulation. 2008 Jan 15;117(2):206-15 - PubMed
  27. J Vasc Surg. 1997 Oct;26(4):585-94 - PubMed
  28. Blood. 2000 Feb 1;95(3):756-68 - PubMed
  29. Stroke. 2004 May;35(5):1079-84 - PubMed
  30. Radiology. 2007 Jul;244(1):64-77 - PubMed
  31. Circulation. 2003 Mar 11;107(9):1322-8 - PubMed
  32. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3422-7 - PubMed
  33. Eur Heart J. 2006 May;27(9):1032-7 - PubMed
  34. Circulation. 2005 May 3;111(17):2203-9 - PubMed
  35. Circulation. 2001 Jun 19;103(24):2885-90 - PubMed
  36. Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1442-7 - PubMed
  37. Arterioscler Thromb Vasc Biol. 1995 Sep;15(9):1512-31 - PubMed
  38. Circ Res. 2004 Aug 20;95(4):343-53 - PubMed
  39. Nat Med. 2001 Jul;7(7):833-9 - PubMed
  40. J Am Coll Cardiol. 2005 Sep 20;46(6):937-54 - PubMed
  41. Nat Med. 2001 Apr;7(4):425-9 - PubMed
  42. Circulation. 2001 Feb 6;103(5):634-7 - PubMed
  43. Oncogene. 2000 Nov 20;19(49):5598-605 - PubMed
  44. J Lipid Res. 2006 Aug;47(8):1677-99 - PubMed
  45. Arch Surg. 1982 Nov;117(11):1479-88 - PubMed
  46. J Neurol. 2007 Dec;254(12):1714-22 - PubMed
  47. Circulation. 2002 Jan 15;105(2):181-5 - PubMed
  48. Circulation. 2002 Jun 25;105(25):3017-24 - PubMed
  49. Circulation. 2002 Sep 10;106(11):1368-73 - PubMed
  50. Circulation. 2004 Nov 16;110(20):3213-20 - PubMed

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