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Takigawa M, Hashimura K, Ishibashi-Ueda H, et al. Annual electrocardiograms consistent with silent progression of cardiac involvement in sporadic familial amyloid polyneuropathy: a case report. Intern Med. 2010;49(2):139-44doi: 10.2169/internalmedicine.49.2703.
Takigawa, M., Hashimura, K., Ishibashi-Ueda, H., Yamada, N., Kiso, K., Nanasato, M., Yoshida, Y., & Hirayama, H. (2010). Annual electrocardiograms consistent with silent progression of cardiac involvement in sporadic familial amyloid polyneuropathy: a case report. Internal medicine (Tokyo, Japan), 49(2), 139-44. https://doi.org/10.2169/internalmedicine.49.2703
Takigawa, Masateru, et al. "Annual electrocardiograms consistent with silent progression of cardiac involvement in sporadic familial amyloid polyneuropathy: a case report." Internal medicine (Tokyo, Japan) vol. 49,2 (2010): 139-44. doi: https://doi.org/10.2169/internalmedicine.49.2703
Takigawa M, Hashimura K, Ishibashi-Ueda H, Yamada N, Kiso K, Nanasato M, Yoshida Y, Hirayama H. Annual electrocardiograms consistent with silent progression of cardiac involvement in sporadic familial amyloid polyneuropathy: a case report. Intern Med. 2010;49(2):139-44. doi: 10.2169/internalmedicine.49.2703. Epub 2010 Jan 15. PMID: 20075578.
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Intern Med. 2010;49(2):139-44. doi: 10.2169/internalmedicine.49.2703. Epub 2010 Jan 15.

Annual electrocardiograms consistent with silent progression of cardiac involvement in sporadic familial amyloid polyneuropathy: a case report.

Internal medicine (Tokyo, Japan)

Masateru Takigawa, Kazuhiko Hashimura, Hatsue Ishibashi-Ueda, Naoaki Yamada, Keisuke Kiso, Mamoru Nanasato, Yukihiko Yoshida, Haruo Hirayama

Affiliations

  1. Cardiovascular Center, Department of Internal Medicine, Japanese Red Cross Society, Nagoya Daini Hospital, Nagoya. [email protected]

PMID: 20075578 DOI: 10.2169/internalmedicine.49.2703

Abstract

Understanding the clinical characteristics of transthyretin familial amyloid polyneuropathy (TTR-FAP) is critical for early diagnosis and timely referral for liver transplantation. Here, we describe a 52-year-old man who had slight paresthesia for four years and whose final diagnosis of TTR-cardiac amyloidosis caused by sporadic FAP was delayed despite annual electrocardiography. Curative liver transplantation was postponed because of progressive cardiac involvement. This experience highlights the difficulties associated with diagnosing TTR-FAP, especially when it is sporadic, and underscores the importance of slight changes in ECG that could indicate FAP.

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