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Tam PM, Hooper CY, Lightman S. Antiviral selection in the management of acute retinal necrosis. Clin Ophthalmol. 2010;4:11-20
Tam, P. M., Hooper, C. Y., & Lightman, S. (2010). Antiviral selection in the management of acute retinal necrosis. Clinical ophthalmology (Auckland, N.Z.), 411-20.
Tam, Patrick M K, et al. "Antiviral selection in the management of acute retinal necrosis." Clinical ophthalmology (Auckland, N.Z.) vol. 4 (2010): 11-20.
Tam PM, Hooper CY, Lightman S. Antiviral selection in the management of acute retinal necrosis. Clin Ophthalmol. 2010 Feb 02;4:11-20. PMID: 20169044; PMCID: PMC2819764.
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Clin Ophthalmol. 2010 Feb 02;4:11-20.

Antiviral selection in the management of acute retinal necrosis.

Clinical ophthalmology (Auckland, N.Z.)

Patrick M K Tam, Claire Y Hooper, Susan Lightman

Affiliations

  1. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, N.T., Hong Kong, People's Republic of China.

PMID: 20169044 PMCID: PMC2819764

Abstract

There is no consensus on the optimal antiviral regimen in the management of acute retinal necrosis, a disease caused by herpetic viruses with devastating consequences for the eye. The current gold standard is based on retrospective case series. Because the incidence of disease is low, few well-designed, randomized trials have evaluated treatment dosage and duration. Newer oral antiviral agents are emerging as alternatives to high-dose intravenous acyclovir, avoiding the need for inpatient intravenous treatment. Drug resistance is uncommon but may also be difficult to identify. Antiviral drugs have few side effects, but special attention needs to be paid to patients who have underlying renal disease, are pregnant or are immunocompromised.

Keywords: acute retinal necrosis; acyclovir; herpes; retinitis

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