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van Niekerk CC, Bulten J, Vooijs GP, et al. The Association between Primary Endometrioid Carcinoma of the Ovary and Synchronous Malignancy of the Endometrium. Obstet Gynecol Int. 2009;2010:465162doi: 10.1155/2010/465162.
van Niekerk, C. C., Bulten, J., Vooijs, G. P., & Verbeek, A. L. (2010). The Association between Primary Endometrioid Carcinoma of the Ovary and Synchronous Malignancy of the Endometrium. Obstetrics and gynecology international, 2010465162. https://doi.org/10.1155/2010/465162
van Niekerk, Catharina C, et al. "The Association between Primary Endometrioid Carcinoma of the Ovary and Synchronous Malignancy of the Endometrium." Obstetrics and gynecology international vol. 2010 (2010): 465162. doi: https://doi.org/10.1155/2010/465162
van Niekerk CC, Bulten J, Vooijs GP, Verbeek AL. The Association between Primary Endometrioid Carcinoma of the Ovary and Synchronous Malignancy of the Endometrium. Obstet Gynecol Int. 2010;2010:465162. doi: 10.1155/2010/465162. Epub 2009 Dec 15. PMID: 20052276; PMCID: PMC2796219.
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Obstet Gynecol Int. 2010;2010:465162. doi: 10.1155/2010/465162. Epub 2009 Dec 15.

The Association between Primary Endometrioid Carcinoma of the Ovary and Synchronous Malignancy of the Endometrium.

Obstetrics and gynecology international

Catharina C van Niekerk, Johan Bulten, G Peter Vooijs, André L M Verbeek

Affiliations

  1. Department of Epidemiology, Biostatistics, and Health Technology Assessment, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

PMID: 20052276 PMCID: PMC2796219 DOI: 10.1155/2010/465162

Abstract

Objective. Ovarian and endometrial cancers coincide rather frequently in the same patient. Few data are available on the involvement of the specific morphological subtypes. To identify histological pathways in the synchronous occurrence, a population-based study was performed in The Netherlands. Methods. Using the national pathology database (PALGA) information of ovarian cancers and of earlier or later cancer in the endometrium was obtained. 5366 Patients were identified with primary malignant epithelial or borderline malignancy. Results. In 157 cases (2.9%) a new primary malignancy in the endometrium was diagnosed (146 within 1 year). The ratio of observed versus expected number of synchronous malignancy in the endometrium was estimated at 3.6 (95% CI: 2.7-4.7). Among 460 ovarian endometrioid carcinoma patients 53 cases showed a second primary endometrial cancer; 40 out of these 53 cases (75.5%) showed at both organ sites an endometrioid adenocarcinoma. Conclusion. These findings suggest an important role for the endometrioid subtype and prompt to mechanism-based studies incorporating molecular techniques.

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