Display options
Cite
Hallström H, Melhus H, Glynn A, et al. Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study. Nutr Metab (Lond). 2010;7:12doi: 10.1186/1743-7075-7-12.
Hallström, H., Melhus, H., Glynn, A., Lind, L., Syvänen, A. C., & Michaëlsson, K. (2010). Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study. Nutrition & metabolism, 712. https://doi.org/10.1186/1743-7075-7-12
Hallström, Helena, et al. "Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study." Nutrition & metabolism vol. 7 (2010): 12. doi: https://doi.org/10.1186/1743-7075-7-12
Hallström H, Melhus H, Glynn A, Lind L, Syvänen AC, Michaëlsson K. Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study. Nutr Metab (Lond). 2010 Feb 22;7:12. doi: 10.1186/1743-7075-7-12. PMID: 20175915; PMCID: PMC2842270.
Copy Download .nbib Format: NLM
Share it on

Nutr Metab (Lond). 2010 Feb 22;7:12. doi: 10.1186/1743-7075-7-12.

Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study.

Nutrition & metabolism

Helena Hallström, Håkan Melhus, Anders Glynn, Lars Lind, Ann-Christine Syvänen, Karl Michaëlsson

Affiliations

  1. Research and Development Department, Toxicology Division, National Food Administration, Box 622, SE-751 26 Uppsala, Sweden. [email protected].

PMID: 20175915 PMCID: PMC2842270 DOI: 10.1186/1743-7075-7-12

Abstract

BACKGROUND: Drinking coffee has been linked to reduced calcium conservation, but it is less clear whether it leads to sustained bone mineral loss and if individual predisposition for caffeine metabolism might be important in this context. Therefore, the relation between consumption of coffee and bone mineral density (BMD) at the proximal femur in men and women was studied, taking into account, for the first time, genotypes for cytochrome P450 1A2 (CYP1A2) associated with metabolism of caffeine.

METHODS: Dietary intakes of 359 men and 358 women (aged 72 years), participants of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), were assessed by a 7-day food diary. Two years later, BMD for total proximal femur, femoral neck and trochanteric regions of the proximal femur were measured by Dual-energy X-ray absorptiometry (DXA). Genotypes of CYP1A2 were determined. Adjusted means of BMD for each category of coffee consumption were calculated.

RESULTS: Men consuming 4 cups of coffee or more per day had 4% lower BMD at the proximal femur (p = 0.04) compared with low or non-consumers of coffee. This difference was not observed in women. In high consumers of coffee, those with rapid metabolism of caffeine (C/C genotype) had lower BMD at the femoral neck (p = 0.01) and at the trochanter (p = 0.03) than slow metabolizers (T/T and C/T genotypes). Calcium intake did not modify the relation between coffee and BMD.

CONCLUSION: High consumption of coffee seems to contribute to a reduction in BMD of the proximal femur in elderly men, but not in women. BMD was lower in high consumers of coffee with rapid metabolism of caffeine, suggesting that rapid metabolizers of caffeine may constitute a risk group for bone loss induced by coffee.

References

  1. Ann Agric Environ Med. 2005;12(1):21-6 - PubMed
  2. Toxicol Lett. 2005 Apr 28;156(3):331-9 - PubMed
  3. Br J Clin Pharmacol. 1989 Apr;27(4):507-14 - PubMed
  4. Rheumatol Int. 2009 Jul;29(9):1025-30 - PubMed
  5. Clin Pharmacol Ther. 1995 Dec;58(6):684-91 - PubMed
  6. Ann Intern Med. 1993 May 1;118(9):657-65 - PubMed
  7. J Orthop Surg Res. 2006 Oct 07;1:7 - PubMed
  8. Braz J Med Biol Res. 1997 Sep;30(9):1061-6 - PubMed
  9. Age Ageing. 1992 Jan;21(1):20-6 - PubMed
  10. J Nutr. 1993 Sep;123(9):1611-4 - PubMed
  11. Int J Mol Sci. 2008 May;9(5):698-718 - PubMed
  12. J Clin Endocrinol Metab. 1995 Feb;80(2):406-11 - PubMed
  13. Cancer Causes Control. 2009 Dec;20(10):2039-44 - PubMed
  14. Osteoporos Int. 2006 Dec;17(12):1726-33 - PubMed
  15. Osteoporos Int. 1996;6(2):149-52 - PubMed
  16. Osteoporos Int. 2001;12(3):222-9 - PubMed
  17. Cold Spring Harb Symp Quant Biol. 2003;68:69-78 - PubMed
  18. Am J Clin Nutr. 1999 Jan;69(1):22-9 - PubMed
  19. J Bone Miner Res. 2000 Apr;15(4):710-20 - PubMed
  20. J Nutr. 1992 May;122(5):1119-26 - PubMed
  21. Br J Clin Pharmacol. 1999 Apr;47(4):445-9 - PubMed
  22. J Hypertens. 2006 Jul;24(7):1319-27 - PubMed
  23. J Bone Miner Res. 2005 Jul;20(7):1185-94 - PubMed
  24. J Clin Endocrinol Metab. 1994 Oct;79(4):950-4 - PubMed
  25. Nutr Metab (Lond). 2006 Feb 15;3:14 - PubMed
  26. Osteoporos Int. 1994 May;4(3):123-8 - PubMed
  27. Food Chem Toxicol. 2002 Sep;40(9):1263-70 - PubMed
  28. J Am Coll Nutr. 2002 Dec;21(6):536-44 - PubMed
  29. Am J Med. 1997 Aug 18;103(2A):20S-25S; discussion 25S-26S - PubMed
  30. J Natl Med Assoc. 2004 Mar;96(3):299-305 - PubMed
  31. Bone. 1997 Dec;21(6):527-33 - PubMed
  32. Lancet. 2002 May 18;359(9319):1761-7 - PubMed
  33. J Am Coll Nutr. 2000 Apr;19(2):256-61 - PubMed
  34. Atherosclerosis. 2009 Mar;203(1):298-303 - PubMed
  35. Liver Int. 2009 Jul;29(6):886-97 - PubMed
  36. PLoS Med. 2007 Jun;4(6):e199 - PubMed
  37. Bone Miner. 1988 Jul;4(3):299-309 - PubMed
  38. J Bone Miner Res. 1992 Apr;7(4):465-71 - PubMed
  39. Osteoporos Int. 1998;8(4):355-63 - PubMed
  40. J Clin Densitom. 2003 Winter;6(4):323-30 - PubMed
  41. Am J Clin Nutr. 1997 Jun;65(6):1826-30 - PubMed
  42. Pharmacogenetics. 2001 Jul;11(5):429-35 - PubMed
  43. JAMA. 2006 Mar 8;295(10):1135-41 - PubMed
  44. Rheumatol Int. 2006 Apr;26(6):530-5 - PubMed
  45. Int Rev Neurobiol. 2008;83:1-10 - PubMed
  46. Osteoporos Int. 1991 Feb;1(2):95-102 - PubMed
  47. Nutrition. 2002 Feb;18(2):189-93 - PubMed
  48. J Lab Clin Med. 1982 Jan;99(1):46-55 - PubMed
  49. J Bone Miner Res. 1995 Nov;10(11):1769-77 - PubMed
  50. Teratology. 1986 Dec;34(3):279-82 - PubMed
  51. Osteoporos Int. 2005 Dec;16(12):1525-37 - PubMed
  52. J Bone Miner Res. 1991 Jul;6(7):651-9 - PubMed
  53. J Bone Miner Res. 1999 Apr;14(4):633-43 - PubMed
  54. Osteoporos Int. 2003 Jan;14(1):34-43 - PubMed
  55. Epidemiology. 1993 Mar;4(2):128-34 - PubMed
  56. JAMA. 1994 Jan 26;271(4):280-3 - PubMed
  57. J Bone Miner Res. 2006 Feb;21(2):228-36 - PubMed
  58. Am J Clin Nutr. 1994 Oct;60(4):573-8 - PubMed
  59. Bone. 2003 Jun;32(6):694-703 - PubMed
  60. Med Hypotheses. 2009 Jul;73(1):83-5 - PubMed
  61. J Am Coll Nutr. 1998 Oct;17(5):454-7 - PubMed
  62. Health Care Women Int. 2002 Sep-Nov;23(6-7):678-91 - PubMed
  63. Curr Pharm Des. 2004;10(21):2593-603 - PubMed

Publication Types