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Pandey MS, Belgamwar VS, Surana SJ. Topical delivery of flurbiprofen from pluronic lecithin organogel. Indian J Pharm Sci. 2009;71(1):87-90doi: 10.4103/0250-474X.51955.
Pandey, M. S., Belgamwar, V. S., & Surana, S. J. (2009). Topical delivery of flurbiprofen from pluronic lecithin organogel. Indian journal of pharmaceutical sciences, 71(1), 87-90. https://doi.org/10.4103/0250-474X.51955
Pandey, M S, et al. "Topical delivery of flurbiprofen from pluronic lecithin organogel." Indian journal of pharmaceutical sciences vol. 71,1 (2009): 87-90. doi: https://doi.org/10.4103/0250-474X.51955
Pandey MS, Belgamwar VS, Surana SJ. Topical delivery of flurbiprofen from pluronic lecithin organogel. Indian J Pharm Sci. 2009 Jan;71(1):87-90. doi: 10.4103/0250-474X.51955. PMID: 20177469; PMCID: PMC2810062.
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Indian J Pharm Sci. 2009 Jan;71(1):87-90. doi: 10.4103/0250-474X.51955.

Topical delivery of flurbiprofen from pluronic lecithin organogel.

Indian journal of pharmaceutical sciences

M S Pandey, V S Belgamwar, S J Surana

Affiliations

  1. Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur-425 405, India.

PMID: 20177469 PMCID: PMC2810062 DOI: 10.4103/0250-474X.51955

Abstract

The purpose of this research is to formulate and evaluate the suitability of pluronic lecithin organogels containing flurbiprofen for topical application. Four formulations were developed using flurbiprofen, lecithin, Pluronic F127, isopropyl palmitate, water, sorbic acid and potassium sorbate were coded as FL1, FL2, FL3 and FL4. All the formulations carried 30% w/w of lecithin phase and 70% w/w of Pluronic phase. The formulated organogels were evaluated for appearance and feel psychorheologically, in vitro diffusion study, drug content, viscosity and pH. Release of flurbiprofen from all formulations was monitored via dialysis membrane-70 and Wistar rat skin as a semipermeable membrane into phosphate buffer saline (0.2 M, pH 7.4) using Keshary-Chien diffusion cell. The viscosities of different formulations were determined by using Brookfield Viscometer at 25 degrees . An attempt has been made to explore the potential of pluronic lecithin organogels for topical delivery of flurbiprofen.

Keywords: Pluronic lecithin organogel; flurbiprofen; topical delivery

References

  1. Biochem Biophys Res Commun. 1991 Jun 28;177(3):897-900 - PubMed
  2. Curr Drug Deliv. 2006 Oct;3(4):417-27 - PubMed
  3. Int J Pharm Compd. 2004 Mar-Apr;8(2):101-5 - PubMed
  4. J Pharm Pharmacol. 2006 Jul;58(7):903-8 - PubMed
  5. AAPS PharmSciTech. 2005 Oct 06;6(2):E298-310 - PubMed
  6. Int J Pharm. 1999 Dec 20;193(1):49-55 - PubMed

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