Display options
Cite
Levy DM, Imundo LF. Nonsteroidal Anti-Inflammatory Drugs: A survey of practices and concerns of pediatric medical and surgical specialists and a summary of available safety data. Pediatr Rheumatol Online J. 2010;8:7doi: 10.1186/1546-0096-8-7.
Levy, D. M., & Imundo, L. F. (2010). Nonsteroidal Anti-Inflammatory Drugs: A survey of practices and concerns of pediatric medical and surgical specialists and a summary of available safety data. Pediatric rheumatology online journal, 87. https://doi.org/10.1186/1546-0096-8-7
Levy, Deborah M, and Imundo, Lisa F. "Nonsteroidal Anti-Inflammatory Drugs: A survey of practices and concerns of pediatric medical and surgical specialists and a summary of available safety data." Pediatric rheumatology online journal vol. 8 (2010): 7. doi: https://doi.org/10.1186/1546-0096-8-7
Levy DM, Imundo LF. Nonsteroidal Anti-Inflammatory Drugs: A survey of practices and concerns of pediatric medical and surgical specialists and a summary of available safety data. Pediatr Rheumatol Online J. 2010 Feb 04;8:7. doi: 10.1186/1546-0096-8-7. PMID: 20181090; PMCID: PMC2831896.
Copy Download .nbib Format: NLM
Share it on

Pediatr Rheumatol Online J. 2010 Feb 04;8:7. doi: 10.1186/1546-0096-8-7.

Nonsteroidal Anti-Inflammatory Drugs: A survey of practices and concerns of pediatric medical and surgical specialists and a summary of available safety data.

Pediatric rheumatology online journal

Deborah M Levy, Lisa F Imundo

Affiliations

  1. Division of Rheumatology, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada. [email protected].

PMID: 20181090 PMCID: PMC2831896 DOI: 10.1186/1546-0096-8-7

Abstract

OBJECTIVES: To examine the prescribing habits of NSAIDs among pediatric medical and surgical practitioners, and to examine concerns and barriers to their use.

METHODS: A sample of 1289 pediatricians, pediatric rheumatologists, sports medicine physicians, pediatric surgeons and pediatric orthopedic surgeons in the United States and Canada were sent an email link to a 22-question web-based survey.

RESULTS: 338 surveys (28%) were completed, 84 were undeliverable. Of all respondents, 164 (50%) had never prescribed a selective cyclooxygenase-2 (COX-2) NSAID. The most common reasons for ever prescribing an NSAID were musculoskeletal pain, soft-tissue injury, fever, arthritis, fracture, and headache. Compared to traditional NSAIDs, selective COX-2 NSAIDs were believed to be as safe (42%) or safer (24%); have equal (52%) to greater efficacy (20%) for pain; have equal (59%) to greater efficacy (15%) for inflammation; and have equal (39%) to improved (44%) tolerability. Pediatric rheumatologists reported significantly more frequent abdominal pain (81% vs. 23%), epistaxis (13% vs. 2%), easy bruising (64% vs. 8%), headaches (21% vs. 1%) and fatigue (12% vs. 1%) for traditional NSAIDs than for selective COX-2 NSAIDs. Prescribing habits of NSAIDs have changed since the voluntary withdrawal of rofecoxib and valdecoxib; 3% of pediatric rheumatologists reported giving fewer traditional NSAID prescriptions, and while 57% reported giving fewer selective COX-2 NSAIDs, 26% reported that they no longer prescribed these medications.

CONCLUSIONS: Traditional and selective COX-2 NSAIDs were perceived as safe by pediatric specialists. The data were compared to the published pediatric safety literature.

References

  1. J Pediatr Orthop. 2003 Nov-Dec;23(6):794-9 - PubMed
  2. JAMA. 1995 Mar 22-29;273(12):929-33 - PubMed
  3. J Pediatr Gastroenterol Nutr. 2007 Apr;44(4):506-8 - PubMed
  4. Ann Pharmacother. 1994 Sep;28(9):1009-13 - PubMed
  5. Fam Pract. 1995 Sep;12(3):335-8 - PubMed
  6. Health Serv Res. 2001 Feb;35(6):1347-55 - PubMed
  7. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):272-7 - PubMed
  8. Br J Gen Pract. 1998 Mar;48(428):1067-9 - PubMed
  9. Paediatr Anaesth. 2005 Feb;15(2):139-42 - PubMed
  10. J Pediatr. 1990 Oct;117(4):645-52 - PubMed
  11. J Med Internet Res. 2004 Oct 29;6(4):e39 - PubMed
  12. Anaesthesia. 2004 Oct;59(10):984-7 - PubMed
  13. Ann Rheum Dis. 1995 Apr;54(4):277-80 - PubMed
  14. Paediatr Anaesth. 2006 Apr;16(4):424-8 - PubMed
  15. Paediatr Anaesth. 2004 Jul;14(7):579-83 - PubMed
  16. J Rheumatol. 1995 Jun;22(6):1149-51 - PubMed
  17. J Cardiothorac Vasc Anesth. 2004 Aug;18(4):454-7 - PubMed
  18. In Vivo. 2006 Jul-Aug;20(4):519-25 - PubMed
  19. Blood. 2006 Mar 1;107(5):1785-90 - PubMed
  20. Anesth Analg. 2003 Jul;97(1):35-8, table of contents - PubMed
  21. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7563-8 - PubMed
  22. Pediatr Nephrol. 2006 Dec;21(12):1893-7 - PubMed
  23. Br J Rheumatol. 1993 Jan;32(1):69-72 - PubMed
  24. BMJ. 2006 Jun 3;332(7553):1302-8 - PubMed
  25. N Engl J Med. 2005 Mar 17;352(11):1081-91 - PubMed
  26. Eval Health Prof. 2007 Dec;30(4):303-21 - PubMed
  27. J Urol. 2001 Nov;166(5):1873-5 - PubMed
  28. Eur J Pediatr. 2001 May;160(5):293-5 - PubMed
  29. Crit Care Med. 1999 Dec;27(12):2786-91 - PubMed
  30. Arthritis Rheum. 2005 Feb;52(2):563-72 - PubMed
  31. Pediatr Emerg Care. 1998 Dec;14(6):416-8 - PubMed
  32. Acta Anaesthesiol Scand. 1998 Aug;42(7):770-5 - PubMed
  33. Pediatrics. 1987 Dec;80(6):904-8 - PubMed
  34. N Engl J Med. 2000 Nov 23;343(21):1520-8, 2 p following 1528 - PubMed
  35. N Engl J Med. 2005 Mar 17;352(11):1071-80 - PubMed
  36. Pediatrics. 2003 Apr;111(4 Pt 1):e299-303 - PubMed
  37. Med Care. 2002 Jul;40(7):596-605 - PubMed
  38. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD004213 - PubMed
  39. Am J Dis Child. 1988 May;142(5):524-5 - PubMed
  40. J Rheumatol. 1982 Jan-Feb;9(1):149-55 - PubMed
  41. Hepatogastroenterology. 1999 Mar-Apr;46(26):991-6 - PubMed
  42. J Rheumatol. 2006 May;33(5):985-95 - PubMed
  43. JAMA. 2000 Sep 13;284(10):1247-55 - PubMed
  44. Clin Pharmacol Ther. 2002 Nov;72(5):490-7 - PubMed
  45. J Pediatr. 1993 Apr;122(4):647-9 - PubMed
  46. Clin Ther. 1999 Oct;21(10):1715-24 - PubMed
  47. Haemophilia. 2006 Sep;12(5):514-7 - PubMed
  48. J Rheumatol. 2002 May;29(5):1079-83 - PubMed
  49. N Engl J Med. 2005 Mar 17;352(11):1092-102 - PubMed
  50. Haemophilia. 2005 May;11(3):240-4 - PubMed

Publication Types

Grant support