Display options
Cite
Isard O, Knol AC, Castex-Rizzi N, et al. Cutaneous induction of corticotropin releasing hormone by Propionibacterium acnes extracts. Dermatoendocrinol. 2009;1(2):96-9doi: 10.4161/derm.1.2.8102.
Isard, O., Knol, A. C., Castex-Rizzi, N., Khammari, A., Charveron, M., & Dréno, B. (2009). Cutaneous induction of corticotropin releasing hormone by Propionibacterium acnes extracts. Dermato-endocrinology, 1(2), 96-9. https://doi.org/10.4161/derm.1.2.8102
Isard, Olivia, et al. "Cutaneous induction of corticotropin releasing hormone by Propionibacterium acnes extracts." Dermato-endocrinology vol. 1,2 (2009): 96-9. doi: https://doi.org/10.4161/derm.1.2.8102
Isard O, Knol AC, Castex-Rizzi N, Khammari A, Charveron M, Dréno B. Cutaneous induction of corticotropin releasing hormone by Propionibacterium acnes extracts. Dermatoendocrinol. 2009 Mar;1(2):96-9. doi: 10.4161/derm.1.2.8102. PMID: 20224691; PMCID: PMC2835898.
Copy Download .nbib Format: NLM
Share it on

Dermatoendocrinol. 2009 Mar;1(2):96-9. doi: 10.4161/derm.1.2.8102.

Cutaneous induction of corticotropin releasing hormone by Propionibacterium acnes extracts.

Dermato-endocrinology

Olivia Isard, Anne-Chantal Knol, Nathalie Castex-Rizzi, Amir Khammari, Marie Charveron, Brigitte Dréno

PMID: 20224691 PMCID: PMC2835898 DOI: 10.4161/derm.1.2.8102

Abstract

The skin commensal bacillus Propionibacterium acnes is known to play a major role in the development of acne vulgaris and it is established that this bacteria is involved both in the induction and maintenance of the inflammatory phase of acne. The corticotropin releasing hormone (CRH), a neuropeptide originally isolated from the hypothalamus, is also produced by the skin. CRH has been reported to play a role in the inflammation, the production of sebum and finally the differentiation of keratinocytes. At the therapeutic level, zinc is known to act specifically on inflammatory lesions with still partially known mechanisms and thus could play an important role in the development of inflammatory acne lesions. Our objective was to study the modulation of CRH expression by keratinocytes induced by P. acnes extracts. CRH expression was examined using immunohistochemistry technique on deep-frozen sections of normal human skin explants incubated with two different extracts of P. acnes and with or without zinc salts. We observed that the membrane fraction (FM) of P. acnes increased the CRH expression in the epidermis. This result indicates that P. acnes, by stimulating the production of CRH, can both modulate the differentiation of keratinocytes and increase the local inflammation, arguing that this bacterium plays a role not only in the development of inflammatory acne lesions but also in the formation of the microcomedo in the early stages of acne.

Keywords: Propionibacterium acnes; acne; corticotropin releasing hormone; stress; zinc

References

  1. Front Biosci. 2007;12:572-80 - PubMed
  2. Br J Dermatol. 2009 Feb;160(2):345-52 - PubMed
  3. Exp Dermatol. 2006 Mar;15(3):143-53 - PubMed
  4. Acta Derm Venereol. 1995 Jan;75(1):19-23 - PubMed
  5. J Invest Dermatol. 2007 Mar;127(3):730-2 - PubMed
  6. Br J Dermatol. 2004 Mar;150(3):421-8 - PubMed
  7. Br J Dermatol. 2005 Jul;153(1):66-71 - PubMed
  8. Science. 2004 Jul 30;305(5684):671-3 - PubMed
  9. Physiol Rev. 2000 Jul;80(3):979-1020 - PubMed
  10. FASEB J. 2001 Aug;15(10):1678-93 - PubMed
  11. Dermatology. 2001;203(2):135-40 - PubMed
  12. FASEB J. 2005 Aug;19(10):1332-4 - PubMed
  13. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7148-53 - PubMed
  14. Exp Dermatol. 2000 Dec;9(6):407-16 - PubMed
  15. J Cell Physiol. 2006 Mar;206(3):780-91 - PubMed
  16. Psychosom Med. 1970 Sep-Oct;32(5):503-8 - PubMed
  17. Acta Derm Venereol. 1992 Aug;72(4):250-2 - PubMed
  18. Int J Dermatol. 1996 Dec;35(12):849-51 - PubMed
  19. Infect Immun. 1995 Aug;63(8):3158-65 - PubMed
  20. J Neuroimmunol. 1997 Feb;72(2):131-6 - PubMed
  21. Eur J Dermatol. 2007 Nov-Dec;17(6):492-6 - PubMed
  22. Exp Dermatol. 2005 Feb;14(2):143-52 - PubMed
  23. Mol Cell Endocrinol. 2007 Feb;265-266:143-9 - PubMed
  24. J Eur Acad Dermatol Venereol. 2001;15 Suppl 3:63-7 - PubMed
  25. Eur J Dermatol. 2005 May-Jun;15(3):152-5 - PubMed
  26. Ann N Y Acad Sci. 2006 Nov;1088:78-99 - PubMed
  27. Br J Dermatol. 2005 Mar;152(3):474-80 - PubMed
  28. J Invest Dermatol. 2005 May;124(5):931-8 - PubMed
  29. Arch Dermatol Res. 2007 Nov;299(9):441-7 - PubMed
  30. Biochim Biophys Acta. 1996 Aug 28;1313(2):130-8 - PubMed
  31. Endocrinology. 2004 Feb;145(2):941-50 - PubMed
  32. N Engl J Med. 1995 May 18;332(20):1351-62 - PubMed
  33. J Invest Dermatol. 1995 May;104(5):775-8 - PubMed
  34. Pediatr Dermatol. 1991 Sep;8(3):185-8 - PubMed
  35. Pigment Cell Res. 1997 Oct;10(5):288-97 - PubMed
  36. Br J Dermatol. 1999 Jan;140(1):26-34 - PubMed
  37. J Am Acad Dermatol. 1984 Jul;11(1):86-9 - PubMed
  38. Trends Pharmacol Sci. 2004 Nov;25(11):563-8 - PubMed
  39. Acta Derm Venereol. 1998 May;78(3):169-72 - PubMed
  40. Br J Dermatol. 2005 Dec;153(6):1105-13 - PubMed
  41. J Invest Dermatol. 2006 Sep;126(9):1934-6 - PubMed
  42. Exp Dermatol. 2004;13 Suppl 4:31-5 - PubMed
  43. J Clin Endocrinol Metab. 1998 Mar;83(3):1020-4 - PubMed
  44. Clin Dermatol. 2004 Sep-Oct;22(5):380-4 - PubMed

Publication Types