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Kumada H, Okanoue T, Onji M, et al. Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan. Hepatol Res. 2010;40(1):8-13doi: 10.1111/j.1872-034X.2009.00634.x.
Kumada, H., Okanoue, T., Onji, M., Moriwaki, H., Izumi, N., Tanaka, E., Chayama, K., Sakisaka, S., Takehara, T., Oketani, M., Suzuki, F., Toyota, J., Nomura, H., Yoshioka, K., Seike, M., Yotsuyanagi, H., Ueno, Y. (2010). Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan. Hepatology research : the official journal of the Japan Society of Hepatology, 40(1), 8-13. https://doi.org/10.1111/j.1872-034X.2009.00634.x
Kumada, Hiromitsu, et al. "Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan." Hepatology research : the official journal of the Japan Society of Hepatology vol. 40,1 (2010): 8-13. doi: https://doi.org/10.1111/j.1872-034X.2009.00634.x
Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y. Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan. Hepatol Res. 2010 Jan;40(1):8-13. doi: 10.1111/j.1872-034X.2009.00634.x. PMID: 20156296.
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Hepatol Res. 2010 Jan;40(1):8-13. doi: 10.1111/j.1872-034X.2009.00634.x.

Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan.

Hepatology research : the official journal of the Japan Society of Hepatology

Hiromitsu Kumada, Takeshi Okanoue, Morikazu Onji, Hisataka Moriwaki, Namiki Izumi, Eiji Tanaka, Kazuaki Chayama, Shotaro Sakisaka, Tetsuo Takehara, Makoto Oketani, Fumitaka Suzuki, Joji Toyota, Hideyuki Nomura, Kentaro Yoshioka, Masataka Seike, Hiroshi Yotsuyanagi, Yoshiyuki Ueno,

Affiliations

  1. Department of Hepatology, Toranomon Hospital, Tokyo.

PMID: 20156296 DOI: 10.1111/j.1872-034X.2009.00634.x

Abstract

In the 2008 guidelines for the treatment of patients with chronic hepatitis C, pegylated interferon (Peg-IFN) combined with ribavirin for 48 weeks are indicated for treatment-naive patients infected with hepatitis C virus (HCV) of genotype 1. Treatment is continued for an additional 24 weeks (72 weeks total) in the patients who have remained positive for HCV RNA detectable by the real-time polymerase chain reaction at 12 weeks after the start of treatment, but who turn negative for HCV RNA during 13-36 weeks on treatment. Re-treatment is aimed to either eradicate HCV or normalize transaminase levels for preventing the development of hepatocellular carcinoma (HCC). For patients with compensated cirrhosis, the clearance of HCV RNA is aimed toward improving histological damages and decreasing the development of HCC. The recommended therapeutic regimen is the initial daily dose of 6 million international units (MIU) IFN continued for 2-8 weeks that is extended to longer than 48 weeks, if possible. IFN dose is reduced to 3 MIU daily in patients who fail to clear HCV RNA by 12 weeks for preventing the development of HCC. Splenectomy or embolization of the splenic artery is recommended to patients with platelet counts of less than 50 x 103/mm(3) prior to the commencement of IFN treatment. When the prevention of HCC is at issue, not only IFN, but also liver supportive therapy such as stronger neo-minophagen C, ursodeoxycholic acid, phlebotomy, branched chain amino acids (BCAA), either alone or in combination, are given. In patients with decompensated cirrhosis, by contrast, reversal to compensation is attempted.

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