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Kim TD, Park JY, Choi I. Post-transcriptional Regulation of NK Cell Activation. Immune Netw. 2009;9(4):115-21doi: 10.4110/in.2009.9.4.115.
Kim, T. D., Park, J. Y., & Choi, I. (2009). Post-transcriptional Regulation of NK Cell Activation. Immune network, 9(4), 115-21. https://doi.org/10.4110/in.2009.9.4.115
Kim, Tae-Don, et al. "Post-transcriptional Regulation of NK Cell Activation." Immune network vol. 9,4 (2009): 115-21. doi: https://doi.org/10.4110/in.2009.9.4.115
Kim TD, Park JY, Choi I. Post-transcriptional Regulation of NK Cell Activation. Immune Netw. 2009 Aug;9(4):115-21. doi: 10.4110/in.2009.9.4.115. Epub 2009 Aug 31. PMID: 20157597; PMCID: PMC2816943.
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Immune Netw. 2009 Aug;9(4):115-21. doi: 10.4110/in.2009.9.4.115. Epub 2009 Aug 31.

Post-transcriptional Regulation of NK Cell Activation.

Immune network

Tae-Don Kim, Ju Yeong Park, Inpyo Choi

Affiliations

  1. Cell Therapy Research Center, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Daejeon 305-806, Korea.

PMID: 20157597 PMCID: PMC2816943 DOI: 10.4110/in.2009.9.4.115

Abstract

Natural killer (NK) cells play key roles in innate and adaptive immune defenses. NK cell responses are mediated by two major mechanisms: the direct cytolysis of target cells, and immune regulation by production of various cytokines. Many previous reports show that the complex NK cell activation process requires de novo gene expression regulated at both transcriptional and post-transcriptional levels. Specialized un-translated regions (UTR) of mRNAs are the main mechanisms of post-transcriptional regulation. Analysis of post-transcriptional regulation is needed to clearly understand NK cell biology and, furthermore, harness the power of NK cells for therapeutic aims. This review summarizes the current understanding of mRNA metabolism during NK cell activation, focusing primarily on post-transcriptional regulation.

Keywords: cytotoxicity; immune regulation; natural killer cells; post-transcriptional regulation

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