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McCombie G, Browning LM, Titman CM, et al. omega-3 oil intake during weight loss in obese women results in remodelling of plasma triglyceride and fatty acids. Metabolomics. 2009;5(3):363-374doi: 10.1007/s11306-009-0161-7.
McCombie, G., Browning, L. M., Titman, C. M., Song, M., Shockcor, J., Jebb, S. A., & Griffin, J. L. (2009). omega-3 oil intake during weight loss in obese women results in remodelling of plasma triglyceride and fatty acids. Metabolomics : Official journal of the Metabolomic Society, 5(3), 363-374. https://doi.org/10.1007/s11306-009-0161-7
McCombie, Gregor, et al. "omega-3 oil intake during weight loss in obese women results in remodelling of plasma triglyceride and fatty acids." Metabolomics : Official journal of the Metabolomic Society vol. 5,3 (2009): 363-374. doi: https://doi.org/10.1007/s11306-009-0161-7
McCombie G, Browning LM, Titman CM, Song M, Shockcor J, Jebb SA, Griffin JL. omega-3 oil intake during weight loss in obese women results in remodelling of plasma triglyceride and fatty acids. Metabolomics. 2009 Sep;5(3):363-374. doi: 10.1007/s11306-009-0161-7. Epub 2009 Apr 26. PMID: 20208976; PMCID: PMC2826632.
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Metabolomics. 2009 Sep;5(3):363-374. doi: 10.1007/s11306-009-0161-7. Epub 2009 Apr 26.

omega-3 oil intake during weight loss in obese women results in remodelling of plasma triglyceride and fatty acids.

Metabolomics : Official journal of the Metabolomic Society

Gregor McCombie, Lucy M Browning, Christopher M Titman, Molly Song, John Shockcor, Susan A Jebb, Julian L Griffin

PMID: 20208976 PMCID: PMC2826632 DOI: 10.1007/s11306-009-0161-7

Abstract

Previous studies have shown that a combination of weight loss and fish oil supplementation reduce cardiovascular disease and diabetes risks by increasing adiponectin and reducing triacylglyceride concentrations, while weight loss alone significantly improves insulin sensitivity and reduces inflammation. Here, a metabolomic approach, using a combination of (1)H-Nuclear Magnetic Resonance spectroscopy, and gas and liquid chromatography and mass spectrometry, was employed to elucidate the metabolic changes in blood plasma following weight loss and fish oil supplementation. The intervention study was conducted over 24 weeks, with 93 female subjects randomised to one of three groups. Two groups followed a 12-week weight loss program, followed by a 12-week weight maintenance period and were randomised to fish or placebo oil capsules; a control group did not follow the weight loss program and were given placebo oil capsules. Lipid profiles changed dramatically upon fish oil intake and subtly across the two weight loss groups. While the fish oil supplementation increased the proportion of various phospholipid species, previously reported reductions in total triacylglycerides (TAGs) upon fish oil intake were shown to be driven by a reduction in a specific subset of the measured TAGs. This remodelling of triglycerides may represent further beneficial effects of fish oil supplementation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11306-009-0161-7) contains supplementary material, which is available to authorized users.

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