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Maia-de-Oliveira JP, Pinto JP, Alexandre V, et al. A false case of clozapine-resistant schizophrenia. Case Rep Med. 2010;2010:534027doi: 10.1155/2010/534027.
Maia-de-Oliveira, J. P., Pinto, J. P., Alexandre, V., Machado-de-Sousa, J. P., Morais, S. L., Chaves, C., Sakamoto, A. C., Zuardi, A. W., Crippa, J. A., & Hallak, J. E. (2010). A false case of clozapine-resistant schizophrenia. Case reports in medicine, 2010534027. https://doi.org/10.1155/2010/534027
Maia-de-Oliveira, J P, et al. "A false case of clozapine-resistant schizophrenia." Case reports in medicine vol. 2010 (2010): 534027. doi: https://doi.org/10.1155/2010/534027
Maia-de-Oliveira JP, Pinto JP, Alexandre V, Machado-de-Sousa JP, Morais SL, Chaves C, Sakamoto AC, Zuardi AW, Crippa JA, Hallak JE. A false case of clozapine-resistant schizophrenia. Case Rep Med. 2010;2010:534027. doi: 10.1155/2010/534027. Epub 2010 Mar 11. PMID: 20300582; PMCID: PMC2837900.
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Case Rep Med. 2010;2010:534027. doi: 10.1155/2010/534027. Epub 2010 Mar 11.

A false case of clozapine-resistant schizophrenia.

Case reports in medicine

J P Maia-de-Oliveira, J P Pinto, V Alexandre, J P Machado-de-Sousa, S L Morais, C Chaves, A C Sakamoto, A W Zuardi, J A S Crippa, J E Hallak

Affiliations

  1. Department of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School, University of São Paulo (USP), Hospital das Clinicas, TerceiroAndar, AvenidaBandeirantes Campus Universitario, 3900, Ribeirao Preto, SP 14049-900, Brazil.

PMID: 20300582 PMCID: PMC2837900 DOI: 10.1155/2010/534027

Abstract

One of the subjects that most concerns physicians is treatment-resistance. About 30%-60% of schizophrenia patients do not respond adequately to antipsychotic treatment and are known as refractory schizophrenia patients. Clozapine has been the drug of choice in such cases. However, approximately 30% of them do not respond to clozapine either. Here, we describe a patient with an initial diagnosis of refractory schizophrenia who had a history of dramatic aggressiveness. However, in this case, "refractoriness" was a wrong diagnosis. A case of psychosis secondary to epilepsy had been treated as schizophrenia for almost 20 years. Reports like this one are important because they remind us of how a thorough investigation can lead to the correct diagnosis and improve the patient's prognosis.

References

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