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Wu AC, Gillman MW, Taveras EM, et al. INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months. Clin Med Pediatr. 2009;3:33-37doi: 10.4137/cmped.s2279.
Wu, A. C., Gillman, M. W., Taveras, E. M., & Litonjua, A. A. (2009). INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months. Clinical medicine. Pediatrics, 333-37. https://doi.org/10.4137/cmped.s2279
Wu, Ann Chen, et al. "INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months." Clinical medicine. Pediatrics vol. 3 (2009): 33-37. doi: https://doi.org/10.4137/cmped.s2279
Wu AC, Gillman MW, Taveras EM, Litonjua AA. INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months. Clin Med Pediatr. 2009;3:33-37. doi: 10.4137/cmped.s2279. PMID: 20354568; PMCID: PMC2846639.
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Clin Med Pediatr. 2009;3:33-37. doi: 10.4137/cmped.s2279.

INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months.

Clinical medicine. Pediatrics

Ann Chen Wu, Matthew W Gillman, Elsie M Taveras, Augusto A Litonjua

Affiliations

  1. Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts, U.S.A.

PMID: 20354568 PMCID: PMC2846639 DOI: 10.4137/cmped.s2279

Abstract

Researchers have described the association of a common DNA polymorphism, rs7566605, near INSIG2 (insulin-induced gene 2) with obesity in multiple independent populations that include subjects ages 11-60 years.1 To our knowledge, no studies have examined the association of this polymorphism with weight status during early childhood. We explored the association of the rs7566605 polymorphism with weight-for-length among 319 children at 6 months and 3 years participating in Project Viva, a pre-birth cohort study. In contrast to studies of older individuals, CC homozygosity was associated with lower gain in weight-for-length z-score between birth and age 6 months than GG homozygosity or GC heterozygosity. At age 3, we did not find an association. The association of INSIG2 gene with obesity may change direction with age.

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