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Choi IS, Han ER, Lim SW, et al. Beta-lactam antibiotic sensitization and its relationship to allergic diseases in tertiary hospital nurses. Allergy Asthma Immunol Res. 2010;2(2):114-22doi: 10.4168/aair.2010.2.2.114.
Choi, I. S., Han, E. R., Lim, S. W., Lim, S. R., Kim, J. N., Park, S. Y., Chae, S. K., Lim, H. H., Seol, Y. A., Bae, Y. I., & Won, Y. H. (2010). Beta-lactam antibiotic sensitization and its relationship to allergic diseases in tertiary hospital nurses. Allergy, asthma & immunology research, 2(2), 114-22. https://doi.org/10.4168/aair.2010.2.2.114
Choi, Inseon S, et al. "Beta-lactam antibiotic sensitization and its relationship to allergic diseases in tertiary hospital nurses." Allergy, asthma & immunology research vol. 2,2 (2010): 114-22. doi: https://doi.org/10.4168/aair.2010.2.2.114
Choi IS, Han ER, Lim SW, Lim SR, Kim JN, Park SY, Chae SK, Lim HH, Seol YA, Bae YI, Won YH. Beta-lactam antibiotic sensitization and its relationship to allergic diseases in tertiary hospital nurses. Allergy Asthma Immunol Res. 2010 Apr;2(2):114-22. doi: 10.4168/aair.2010.2.2.114. Epub 2010 Mar 24. PMID: 20358025; PMCID: PMC2846734.
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Allergy Asthma Immunol Res. 2010 Apr;2(2):114-22. doi: 10.4168/aair.2010.2.2.114. Epub 2010 Mar 24.

Beta-lactam antibiotic sensitization and its relationship to allergic diseases in tertiary hospital nurses.

Allergy, asthma & immunology research

Inseon S Choi, Eui-Ryoung Han, Seong-Wook Lim, Seong-Ryoon Lim, Ji-Na Kim, Sin-Young Park, Su-Kyoung Chae, Hye-Hyeun Lim, Young-Ae Seol, You-In Bae, Young-Ho Won

Affiliations

  1. Allergy Division of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.

PMID: 20358025 PMCID: PMC2846734 DOI: 10.4168/aair.2010.2.2.114

Abstract

PURPOSE: Skin allergies through type 1 and 4 hypersensitivity reactions are the most frequent manifestations of drug allergies. We had previously experienced a case of a nurse with cefotiam-induced contact urticaria syndrome. To aid in preventing the progression of drug-induced allergic disease in nurses, we conducted a survey of tertiary hospital nurses who were likely to have been exposed professionally to antibiotics.

METHODS: All 539 staff nurses at a tertiary hospital were asked to respond to a questionnaire regarding antibiotic exposure. Of the 457 nurses (84.8%) who responded, 427 (79.2%) received a physical examination of the hands and 318 (59.0%) received skin prick tests with the beta-lactam antibiotics cefotiam, cefoperazone, ceftizoxime, flomoxef, piperacillin and penicillin G.

RESULTS: A positive response to at least one of the antibiotics occurred in 8 (2.6%) of the 311 subjects included in the analysis and stages 1 and 2 contact urticaria syndrome were observed in 38 (8.9%) and 3 (0.7%) of 427 nurses, respectively. The frequencies of a positive antibiotic skin test (6.9 versus 1.3%, chi(2)=7.15, P=0.018), stage 1 contact urticaria syndrome (14.4 versus 7.4%, chi(2)=4.33, P=0.038) and drug allergy (15.3 versus 3.6%, chi(2)=18.28, P=0.000) were higher in subjects with a positive skin allergy history than in those without. Allergic rhinitis (P=0.02, OR=3.86, CI=1.23-12.06), night cough (P=0.04, OR=3.12, CI=1.03-9.41) and food allergy (P=0.00, OR=9.90, CI=3.38-29.98) were significant risk factors for drug allergy.

CONCLUSIONS: Antibiotic sensitization and drug allergy occurred more frequently in nurses with a positive skin allergy history. Atopy may be an important risk factor for drug allergy.

Keywords: Drug hypersensitivity; beta-lactam antibiotics; contact urticaria syndrome; nurses

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