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Alvarez JA, Bush NC, Choquette SS, et al. Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women. Nutr Metab (Lond). 2010;7:28doi: 10.1186/1743-7075-7-28.
Alvarez, J. A., Bush, N. C., Choquette, S. S., Hunter, G. R., Darnell, B. E., Oster, R. A., & Gower, B. A. (2010). Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women. Nutrition & metabolism, 728. https://doi.org/10.1186/1743-7075-7-28
Alvarez, Jessica A, et al. "Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women." Nutrition & metabolism vol. 7 (2010): 28. doi: https://doi.org/10.1186/1743-7075-7-28
Alvarez JA, Bush NC, Choquette SS, Hunter GR, Darnell BE, Oster RA, Gower BA. Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women. Nutr Metab (Lond). 2010 Apr 14;7:28. doi: 10.1186/1743-7075-7-28. PMID: 20398267; PMCID: PMC2868016.
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Nutr Metab (Lond). 2010 Apr 14;7:28. doi: 10.1186/1743-7075-7-28.

Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women.

Nutrition & metabolism

Jessica A Alvarez, Nikki C Bush, Suzanne S Choquette, Gary R Hunter, Betty E Darnell, Robert A Oster, Barbara A Gower

Affiliations

  1. Department of Nutrition Sciences, University of Alabama at Birmingham, 1625 University Blvd, Birmingham, Alabama, 35294, USA. [email protected].

PMID: 20398267 PMCID: PMC2868016 DOI: 10.1186/1743-7075-7-28

Abstract

BACKGROUND: The prevalence of type 2 diabetes is higher among African Americans (AA) vs European Americans (EA), independent of obesity and other known confounders. Although the reason for this disparity is not known, it is possible that relatively low levels of vitamin D among AA may contribute, as vitamin D has been positively associated with insulin sensitivity in some studies. The objective of this study was to test the hypothesis that dietary vitamin D would be associated with a robust measure of insulin sensitivity in AA and EA women.

METHODS: Subjects were 115 African American (AA) and 137 European American (EA) healthy, premenopausal women. Dietary intake was determined with 4-day food records; the insulin sensitivity index (SI) with a frequently-sampled intravenous glucose tolerance test and minimal modeling; the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) with fasting insulin and glucose; and body composition with dual-energy X-ray absorptiometry.

RESULTS: Vitamin D intake was positively associated with SI (standardized beta = 0.18, P = 0.05) and inversely associated with HOMA-IR (standardized beta = -0.26, P = 0.007) in AA, and the relationships were independent of age, total body fat, energy intake, and % kcal from fat. Vitamin D intake was not significantly associated with indices of insulin sensitivity/resistance in EA (standardized beta = 0.03, P = 0.74 and standardized beta = 0.02, P = 0.85 for SI and HOMA-IR, respectively). Similar to vitamin D, dietary calcium was associated with SI and HOMA-IR among AA but not EA.

CONCLUSIONS: This study provides novel findings that dietary vitamin D and calcium were independently associated with insulin sensitivity in AA, but not EA. Promotion of these nutrients in the diet may reduce health disparities in type 2 diabetes risk among AA, although longitudinal and intervention studies are required.

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