Display options
Cite
Lim SH, Kim DH, Park MJ, et al. Is Metabolic Syndrome One of the Risk Factors for Gallbladder Polyps Found by Ultrasonography during Health Screening?. Gut Liver. 2007;1(2):138-44doi: 10.5009/gnl.2007.1.2.138.
Lim, S. H., Kim, D. H., Park, M. J., Kim, Y. S., Kim, C. H., Yim, J. Y., Cho, K. R., Kim, S. S., Choi, S. H., Kim, N., Cho, S. H., & Oh, B. H. (2007). Is Metabolic Syndrome One of the Risk Factors for Gallbladder Polyps Found by Ultrasonography during Health Screening?. Gut and liver, 1(2), 138-44. https://doi.org/10.5009/gnl.2007.1.2.138
Lim, Seon Hee, et al. "Is Metabolic Syndrome One of the Risk Factors for Gallbladder Polyps Found by Ultrasonography during Health Screening?." Gut and liver vol. 1,2 (2007): 138-44. doi: https://doi.org/10.5009/gnl.2007.1.2.138
Lim SH, Kim DH, Park MJ, Kim YS, Kim CH, Yim JY, Cho KR, Kim SS, Choi SH, Kim N, Cho SH, Oh BH. Is Metabolic Syndrome One of the Risk Factors for Gallbladder Polyps Found by Ultrasonography during Health Screening?. Gut Liver. 2007 Dec;1(2):138-44. doi: 10.5009/gnl.2007.1.2.138. Epub 2007 Dec 31. PMID: 20485630; PMCID: PMC2871628.
Copy Download .nbib Format: NLM
Share it on

Gut Liver. 2007 Dec;1(2):138-44. doi: 10.5009/gnl.2007.1.2.138. Epub 2007 Dec 31.

Is Metabolic Syndrome One of the Risk Factors for Gallbladder Polyps Found by Ultrasonography during Health Screening?.

Gut and liver

Seon Hee Lim, Dong Hee Kim, Min Jung Park, Young Sun Kim, Chung Hyun Kim, Jung Yun Yim, Kyung Ran Cho, Sun Sin Kim, Seung Ho Choi, Nayoung Kim, Sang Heon Cho, Byung-Hee Oh

Affiliations

  1. Healthcare System Gangnam Center, Healthcare Research Institute, Seoul National University Hospital, Seoul, Korea.

PMID: 20485630 PMCID: PMC2871628 DOI: 10.5009/gnl.2007.1.2.138

Abstract

BACKGROUND/AIMS: We conducted this study to identify the risk factors for finding gallbladder polyps (GBP) in Korean subjects during health screening, and to determine the nature of the association between the presence of metabolic syndrome (MS) and the development of GBP METHODS: A total of 1,523 subjects were enrolled, comprising 264 with GBP (81 women and 183 men) and 1,259 controls (696 women and 563 men with normal GB). Body mass index (BMI), waist circumference (WC), blood pressure (BP), insulin, fasting blood sugar (FBS), lipids, liver enzymes, hepatitis B antigens (HBs Ag), and hepatitis C antibodies (HCV Ab) were measured. MS was considered to be present when three or more of the NCEP-ATPIII (National Cholesterol Education Program-Adult Treatment Panel III) criteria were satisfied. Insulin resistance was calculated by homeostasis model assessment of insulin resistance (HOMA-IR). Independent risk factors were analyzed by logistic regression analysis.

RESULTS: Univariate analysis revealed that the risk factors for GBP were age, sex, WC, smoking history, BP, BMI, FBS, serum lipids, HOMA-IR score, and MS. Multivariate logistic regression analysis revealed that the risk factors for GBP were presence of MS (Odds Ratio (OR)=2.35, 95%Confidence Interval (CI)=1.53-3.60), being male (OR=2.34, 95%CI=1.72-3.18), HOMA-IR score>2.5 (OR=1.64, 95%CI=1.19-2.26), and higher WC (OR=1.4, 95%CI=1.05-1.88). MS was present in 20.8% and 5.9% of GBP patients and controls, respectively, and was the highest risk factor for GBP.

CONCLUSIONS: MS, male, insulin resistance, and abdominal obesity are probably risk factors for GBP, with MS appearing to be strongly associated with GBP in Koreans.

Keywords: Gallbladder polyp; Insulin resistance; Metabolic syndrome; Risk factor

References

  1. Circulation. 2002 Dec 17;106(25):3143-421 - PubMed
  2. Am J Surg. 2004 Aug;188(2):186-90 - PubMed
  3. Exp Mol Pathol. 1977 Dec;27(3):324-38 - PubMed
  4. J Ultrasound Med. 1998 Apr;17(4):207-11 - PubMed
  5. J Clin Gastroenterol. 1996 Sep;23(2):158-9 - PubMed
  6. Diabetes Care. 2005 Jul;28(7):1810-2 - PubMed
  7. Scand J Gastroenterol. 1990 Mar;25(3):281-6 - PubMed
  8. Am J Gastroenterol. 1998 Sep;93(9):1518-23 - PubMed
  9. Korean J Gastroenterol. 2006 Nov;48(5):344-50 - PubMed
  10. Br J Surg. 1992 Mar;79(3):227-9 - PubMed
  11. J Gastroenterol. 2002;37(6):455-62 - PubMed
  12. Am J Gastroenterol. 1997 Nov;92(11):2066-8 - PubMed
  13. J Surg Oncol. 1986 May;32(1):16-8 - PubMed
  14. Am J Gastroenterol. 1992 May;87(5):630-3 - PubMed
  15. Gastroenterology. 1982 Apr;82(4):607-15 - PubMed
  16. Diabetologia. 1985 Jul;28(7):412-9 - PubMed
  17. Scand J Gastroenterol. 1994 Jan;29(1):7-10 - PubMed

Publication Types