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Wiecek J, Kovala-Demertzi D, Ciunik Z, et al. Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone: Synthesis, Crystal Structure, and Antiproliferative Activity. Bioinorg Chem Appl. 2010;718606doi: 10.1155/2010/718606.
Wiecek, J., Kovala-Demertzi, D., Ciunik, Z., Wietrzyk, J., Zervou, M., & Demertzis, M. A. (2010). Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone: Synthesis, Crystal Structure, and Antiproliferative Activity. Bioinorganic chemistry and applications, 718606. https://doi.org/10.1155/2010/718606
Wiecek, Joanna, et al. "Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone: Synthesis, Crystal Structure, and Antiproliferative Activity." Bioinorganic chemistry and applications vol. (2010): 718606. doi: https://doi.org/10.1155/2010/718606
Wiecek J, Kovala-Demertzi D, Ciunik Z, Wietrzyk J, Zervou M, Demertzis MA. Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone: Synthesis, Crystal Structure, and Antiproliferative Activity. Bioinorg Chem Appl. 2010;718606. doi: 10.1155/2010/718606. Epub 2010 May 12. PMID: 20490260; PMCID: PMC2869176.
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Bioinorg Chem Appl. 2010;718606. doi: 10.1155/2010/718606. Epub 2010 May 12.

Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone: Synthesis, Crystal Structure, and Antiproliferative Activity.

Bioinorganic chemistry and applications

Joanna Wiecek, Dimitra Kovala-Demertzi, Zbigniew Ciunik, Joanna Wietrzyk, Maria Zervou, Mavroudis A Demertzis

Affiliations

  1. Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.

PMID: 20490260 PMCID: PMC2869176 DOI: 10.1155/2010/718606

Abstract

The novel diphenyltin(IV) compound [Ph(2)(HyFoSc)Sn] (2), where H(2)HyFoSc (1) is 3-hydroxy-2-formylpyridine semicarbazone, was prepared and characterized by vibrational and NMR ((1)H, (13)C) spectroscopy. The structure of [Ph(2)(HyFoSc)Sn] was confirmed by single-crystal X-ray crystallography. The doubly deprotonated ligand is coordinated to the tin atom through the enolic-oxygen, the azomethine-nitrogen, and phenolic-oxygen, and so acts as an anionic tridentate ligand with the ONO donors. Two carbon atoms complete the fivefold coordination at the tin(IV) center. Intermolecular hydrogen bonding, C-H --> pi, and pi --> pi interactions combine to stabilize the crystal structure. Compounds 1 and 2 have been evaluated for antiproliferative activity in vitro against the cells of three human tumor cell lines: MCF-7 (human breast cancer cell line), T24 (bladder cancer cell line), A549 (nonsmall cell lung carcinoma), and a mouse fibroblast L-929 cancer cell line.

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