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Urita Y, Watanabe T, Ota H, et al. High prevalence of gastroesophageal reflux symptoms in patients with both acute and nonacute cough. Int J Gen Med. 2008;1:59-63doi: 10.2147/ijgm.s4185.
Urita, Y., Watanabe, T., Ota, H., Iwata, M., Sasaki, Y., Maeda, T., Ishii, T., Nanami, M., Nakayama, A., Kato, H., Hike, K., Hara, N., Sanaka, M., Nagai, Y., Watanabe, S., Nakanishi, K., Nakajima, H., & Sugimoto, M. (2008). High prevalence of gastroesophageal reflux symptoms in patients with both acute and nonacute cough. International journal of general medicine, 159-63. https://doi.org/10.2147/ijgm.s4185
Urita, Yoshihisa, et al. "High prevalence of gastroesophageal reflux symptoms in patients with both acute and nonacute cough." International journal of general medicine vol. 1 (2008): 59-63. doi: https://doi.org/10.2147/ijgm.s4185
Urita Y, Watanabe T, Ota H, Iwata M, Sasaki Y, Maeda T, Ishii T, Nanami M, Nakayama A, Kato H, Hike K, Hara N, Sanaka M, Nagai Y, Watanabe S, Nakanishi K, Nakajima H, Sugimoto M. High prevalence of gastroesophageal reflux symptoms in patients with both acute and nonacute cough. Int J Gen Med. 2008 Nov 30;1:59-63. doi: 10.2147/ijgm.s4185. PMID: 20428407; PMCID: PMC2840545.
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Int J Gen Med. 2008 Nov 30;1:59-63. doi: 10.2147/ijgm.s4185.

High prevalence of gastroesophageal reflux symptoms in patients with both acute and nonacute cough.

International journal of general medicine

Yoshihisa Urita, Toshiyasu Watanabe, Hiroki Ota, Motohide Iwata, Yosuke Sasaki, Tadashi Maeda, Takamasa Ishii, Makie Nanami, Asuka Nakayama, Hirohito Kato, Kazuo Hike, Noriko Hara, Masaki Sanaka, Yoko Nagai, Shuji Watanabe, Kazushige Nakanishi, Hitoshi Nakajima, Motonobu Sugimoto

Affiliations

  1. Department of General Medicine and Emergency Care, Toho University School of Medicine, Omori Hospital, Tokyo, Japan.

PMID: 20428407 PMCID: PMC2840545 DOI: 10.2147/ijgm.s4185

Abstract

Although there have been many studies that showed a close association between gastroesophageal reflux disease (GERD) symptoms and chronic cough, it has been unknown whether acute cough is also associated with GERD. The aim of this study was to evaluate the relationship between GERD and respiratory symptoms in general practice. 1725 consecutive patients who first attended our hospital were enrolled in the present study. They were asked to respond the F-scale questionnaire regardless of their chief complaints. Over all, 656 (38%) patients were diagnosed as GERD and 226 (13%) had respiratory symptoms. Patients with respiratory symptoms had GERD symptoms more frequently than patients without respiratory symptoms (p < 0.05). Forty-three (37%) of 115 patients with acute cough and 48 (43%) of 111 with nonacute cough had GERD symptoms, suggesting that development of GERD is not associated with the period of respiratory symptoms. Patients with respiratory symptoms are at a significantly increased risk of developing GERD. Whether or not treatment for GERD or respiratory diseases is useful for the prevention of respiratory symptoms and GERD, respectively, should not be driving management decisions in primary care.

Keywords: F-scale; acute cough; chronic cough; gastroesophageal reflux

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