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Paliwal SK, Chauhan R, Sharma V, et al. Entrapment of ketorolac tromethamine in polymeric vehicle for controlled drug delivery. Indian J Pharm Sci. 2009;71(6):687-91doi: 10.4103/0250-474X.59555.
Paliwal, S. K., Chauhan, R., Sharma, V., Majumdar, D. K., & Paliwal, S. (2009). Entrapment of ketorolac tromethamine in polymeric vehicle for controlled drug delivery. Indian journal of pharmaceutical sciences, 71(6), 687-91. https://doi.org/10.4103/0250-474X.59555
Paliwal, S K, et al. "Entrapment of ketorolac tromethamine in polymeric vehicle for controlled drug delivery." Indian journal of pharmaceutical sciences vol. 71,6 (2009): 687-91. doi: https://doi.org/10.4103/0250-474X.59555
Paliwal SK, Chauhan R, Sharma V, Majumdar DK, Paliwal S. Entrapment of ketorolac tromethamine in polymeric vehicle for controlled drug delivery. Indian J Pharm Sci. 2009 Nov;71(6):687-91. doi: 10.4103/0250-474X.59555. PMID: 20376226; PMCID: PMC2846478.
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Indian J Pharm Sci. 2009 Nov;71(6):687-91. doi: 10.4103/0250-474X.59555.

Entrapment of ketorolac tromethamine in polymeric vehicle for controlled drug delivery.

Indian journal of pharmaceutical sciences

S K Paliwal, Rajani Chauhan, Veena Sharma, D K Majumdar, S Paliwal

Affiliations

  1. Department of Pharmaceutical Science, Faculty of life Sciences, Banasthali Vidyapith-304 022, India.

PMID: 20376226 PMCID: PMC2846478 DOI: 10.4103/0250-474X.59555

Abstract

The most common method for applying a drug in to the eye is to formulate the drug in the form of an eye drop, but this method is not considered ideal for ocular delivery of drug because of poor bioavailability arising from precorneal loss processes, this loss of drug from the precorneal area is a net effect of drainage, tear secretion and noncorneal absorption. Following the above lead we tried to improve the ocular bioavailability by increasing the corneal contact time and the feasible way was to formulate a drug with mucoadhesive/viscosity imparting agents. The adhesive strength of various polymers on corneal surface was studied with the help of self modified Franz diffusion cell and freshly excised goat/bovine cornea. The polymers hydroxypropylmethylcellulose, carboxymethylcellulose sodium, Eudragit type E/RL/RS, Carbopol ETD 2020 and Carbopol 934 National Formulary were formulated with drug, ketorolac tromethamine. The adhesive strength of polymers on corneal surface and permeation characteristics of drug through cornea were investigated by using above said formulations. Eudragit type E/RL/RS did not show any improvement in mucoadhesion, but the formulations containing Carbopol ETD 2020 and Carbopol 934 national formulary showed good mucoadhesion on corneal surface in the concentration as low as 0.75%. The mucoadhesive strength was also evaluated using the combination of Carbopol acrylates/C 10-30 alkylacrylate with allylpentaerithrital and preservative benzalkonium chloride, which also resulted in good mucoadhesion with improved corneal permeation. Observations made in this study indicate the potentiality of the ophthalmic formulations containing mucoadhesive/viscosity imparting agents.

Keywords: Corneal permeation; controlled drug delivery; goat eye; ketorolac tromethamine; polymeric vehicle

References

  1. J Control Release. 2000 May 15;66(2-3):281-92 - PubMed
  2. J Pharm Sci. 1988 Jan;77(1):15-23 - PubMed
  3. J Drug Target. 2006 Apr;14(3):147-54 - PubMed
  4. J Pharm Sci. 2000 Jul;89(7):850-66 - PubMed
  5. Drugs. 1997 Jan;53(1):139-88 - PubMed
  6. J Pharm Pharmacol. 2005 Jan;57(1):3-22 - PubMed
  7. CMAJ. 1993 May 15;148(10):1693-5 - PubMed
  8. J Pharm Sci. 1988 Jan;77(1):3-14 - PubMed
  9. Drugs. 1990 Jan;39(1):86-109 - PubMed
  10. Adv Drug Deliv Rev. 2004 Sep 22;56(11):1675-87 - PubMed
  11. Nanomedicine. 2006 Mar;2(1):8-21 - PubMed
  12. Cornea. 2006 Feb;25(2):182-4 - PubMed
  13. Clin Pharmacokinet. 2001;40(2):77-84 - PubMed
  14. Curr Probl Dermatol. 1978;7:58-68 - PubMed
  15. Yakugaku Zasshi. 2001 Mar;121(3):239-45 - PubMed

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