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Johannessen JN, Kelner L, Hanselman D, et al. In vitro oxidation of MPTP by primate neural tissue: A potential model of MPTP neurotoxicity. Neurochem Int. 1985;7(1):169-76doi: 10.1016/0197-0186(85)90022-1.
Johannessen, J. N., Kelner, L., Hanselman, D., Shih, M. C., & Markey, S. P. (1985). In vitro oxidation of MPTP by primate neural tissue: A potential model of MPTP neurotoxicity. Neurochemistry international, 7(1), 169-76. https://doi.org/10.1016/0197-0186(85)90022-1
Johannessen, J N, et al. "In vitro oxidation of MPTP by primate neural tissue: A potential model of MPTP neurotoxicity." Neurochemistry international vol. 7,1 (1985): 169-76. doi: https://doi.org/10.1016/0197-0186(85)90022-1
Johannessen JN, Kelner L, Hanselman D, Shih MC, Markey SP. In vitro oxidation of MPTP by primate neural tissue: A potential model of MPTP neurotoxicity. Neurochem Int. 1985;7(1):169-76. doi: 10.1016/0197-0186(85)90022-1. PMID: 20492913.
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Neurochem Int. 1985;7(1):169-76. doi: 10.1016/0197-0186(85)90022-1.

In vitro oxidation of MPTP by primate neural tissue: A potential model of MPTP neurotoxicity.

Neurochemistry international

J N Johannessen, L Kelner, D Hanselman, M C Shih, S P Markey

Affiliations

  1. Laboratory of Clinical Science, NIMH, Bethesda, MD 20205, USA.

PMID: 20492913 DOI: 10.1016/0197-0186(85)90022-1

Abstract

The compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces a parkinsonian syndrome in humans and primates. We have previously found that metabolism of MPTP to a quaternary species is necessary for the expression of its neurotoxic effects. We now report that the metabolism of MPTP occurs in primate brain tissue in vitro , and present a model of MPTP neurotoxicity which incorporates our findings to date. Since the toxicity of MPTP is metabolism dependent, we propose that the in vitro metabolism of MPTP by brain tissue should provide a useful model for studying selected aspects of MPTP neurotoxicity.

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