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Aguilar JS, Ochoa EL. The heterogeneity and nucleotide modulation of cholinergic muscarinic receptors are restored by poly (ethylene) glycol-6000 precipitation of solubilized atrial receptors. Neurochem Int. 1986;8(1):47-51doi: 10.1016/0197-0186(86)90099-9.
Aguilar, J. S., & Ochoa, E. L. (1986). The heterogeneity and nucleotide modulation of cholinergic muscarinic receptors are restored by poly (ethylene) glycol-6000 precipitation of solubilized atrial receptors. Neurochemistry international, 8(1), 47-51. https://doi.org/10.1016/0197-0186(86)90099-9
Aguilar, J S, and Ochoa, E L. "The heterogeneity and nucleotide modulation of cholinergic muscarinic receptors are restored by poly (ethylene) glycol-6000 precipitation of solubilized atrial receptors." Neurochemistry international vol. 8,1 (1986): 47-51. doi: https://doi.org/10.1016/0197-0186(86)90099-9
Aguilar JS, Ochoa EL. The heterogeneity and nucleotide modulation of cholinergic muscarinic receptors are restored by poly (ethylene) glycol-6000 precipitation of solubilized atrial receptors. Neurochem Int. 1986;8(1):47-51. doi: 10.1016/0197-0186(86)90099-9. PMID: 20493028.
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Neurochem Int. 1986;8(1):47-51. doi: 10.1016/0197-0186(86)90099-9.

The heterogeneity and nucleotide modulation of cholinergic muscarinic receptors are restored by poly (ethylene) glycol-6000 precipitation of solubilized atrial receptors.

Neurochemistry international

J S Aguilar, E L Ochoa

Affiliations

  1. Instituto de Biologia Celular, Facultad de Medicina Universidad de Buenos Aires, 1121 Buenos Aires, Argentina.

PMID: 20493028 DOI: 10.1016/0197-0186(86)90099-9

Abstract

The membrane bound muscarinic receptor exhibits heterogeneity of binding sites for agonists that are modulated by guanine nucleotides. These properties are generally lost upon receptor solubilization by several detergents, but may be recovered after rapid detergent removal by poly (ethylene) glycol-6000 precipitation of the digitonin plus cholate solubilized atrial muscarinic receptor. The results are discussed in terms of muscarinic receptor interactions in the intact membrane.

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