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Campese VM, Ye S. A vitamin-E-fortified diet reduces oxidative stress, sympathetic nerve activity, and hypertension in the phenol-renal injury model in rats. J Am Soc Hypertens. 2007;1(4):242-50doi: 10.1016/j.jash.2007.04.003.
Campese, V. M., & Ye, S. (2007). A vitamin-E-fortified diet reduces oxidative stress, sympathetic nerve activity, and hypertension in the phenol-renal injury model in rats. Journal of the American Society of Hypertension : JASH, 1(4), 242-50. https://doi.org/10.1016/j.jash.2007.04.003
Campese, Vito M, and Ye, Shaohua. "A vitamin-E-fortified diet reduces oxidative stress, sympathetic nerve activity, and hypertension in the phenol-renal injury model in rats." Journal of the American Society of Hypertension : JASH vol. 1,4 (2007): 242-50. doi: https://doi.org/10.1016/j.jash.2007.04.003
Campese VM, Ye S. A vitamin-E-fortified diet reduces oxidative stress, sympathetic nerve activity, and hypertension in the phenol-renal injury model in rats. J Am Soc Hypertens. 2007 Jul-Aug;1(4):242-50. doi: 10.1016/j.jash.2007.04.003. PMID: 20409856.
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J Am Soc Hypertens. 2007 Jul-Aug;1(4):242-50. doi: 10.1016/j.jash.2007.04.003.

A vitamin-E-fortified diet reduces oxidative stress, sympathetic nerve activity, and hypertension in the phenol-renal injury model in rats.

Journal of the American Society of Hypertension : JASH

Vito M Campese, Shaohua Ye

Affiliations

  1. Division of Nephrology; and the Hypertension Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

PMID: 20409856 DOI: 10.1016/j.jash.2007.04.003

Abstract

Renal injury caused by the injection of phenol in the lower pole of one kidney increases sympathetic nervous system (SNS) activity and blood pressure (BP), and these effects are mediated by increased reactive oxygen species (ROS) in brain nuclei involved in the noradrenergic control of BP. This suggests that therapy with antioxidants might be beneficial in this model. In this study, we tested the hypothesis that a vitamin (Vit)-E-enriched diet might decrease oxidative stress in the brain and result in reduced SNS activity and BP in animals with phenol-renal injury. To this end, we examined the effects of a Vit-E-fortified diet vs. a control diet on BP, norepinephrine (NE) secretion from the posterior hypothalamic nuclei (PH), and the abundance of several components of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase in the brain of rats with phenol-induced renal injury. A Vit-E-fortified diet mitigated the formation of ROS in the brain, and this was associated with reduced SNS activity and BP in rats with phenol-induced renal injury. In conclusion, antioxidants appear to be beneficial in the management of hypertension caused by renal injury and increased SNS activity.

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