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Shin DS, Park JW, Suh JY, et al. The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus. J Periodontal Implant Sci. 2010;40(1):33-8doi: 10.5051/jpis.2010.40.1.33.
Shin, D. S., Park, J. W., Suh, J. Y., & Lee, J. M. (2010). The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus. Journal of periodontal & implant science, 40(1), 33-8. https://doi.org/10.5051/jpis.2010.40.1.33
Shin, Dong-Seok, et al. "The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus." Journal of periodontal & implant science vol. 40,1 (2010): 33-8. doi: https://doi.org/10.5051/jpis.2010.40.1.33
Shin DS, Park JW, Suh JY, Lee JM. The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus. J Periodontal Implant Sci. 2010 Feb;40(1):33-8. doi: 10.5051/jpis.2010.40.1.33. Epub 2010 Feb 28. PMID: 20498757; PMCID: PMC2872806.
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J Periodontal Implant Sci. 2010 Feb;40(1):33-8. doi: 10.5051/jpis.2010.40.1.33. Epub 2010 Feb 28.

The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus.

Journal of periodontal & implant science

Dong-Seok Shin, Jin-Woo Park, Jo-Young Suh, Jae-Mok Lee

Affiliations

  1. Department of Periodontology, Kyungpook National University School of Dentistry, Daegu, Korea.

PMID: 20498757 PMCID: PMC2872806 DOI: 10.5051/jpis.2010.40.1.33

Abstract

PURPOSE: The purpose of this study was to observe and quantify the expression of interleukin-4 (IL-4), interferon-gamma (IFN-gamma), and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in the gingival tissue of patients with type 2 diabetes mellitus (DM) and healthy adults with chronic periodontitis.

METHODS: Twelve patients with type 2 DM and chronic periodontitis (Group 3), twelve patients with chronic periodontitis (Group 2), and twelve healthy individuals (Group 1) were included in the study. Clinical criteria of gingival (sulcus bleeding index value, probing depths) and radiographic evidences of bone resorption were divided into three groups. The concentrations of cytokines were determined by a western blot analysis and compared using one-way ANOVA followed by Tukey's test.

RESULTS: The expression levels of IFN-gamma and TIMP-2 showed an increasing tendency in Groups 2 and 3 when compared to Group 1. On the other hand, the expression of IL-4 was highest in Group 1.

CONCLUSIONS: The findings suggest that IFN-gamma and TIMP-2 may be involved in the periodontal inflammation associated with type 2 DM. IL-4 may be involved in the retrogression of the periodontal inflammation associated with type 2 DM.

Keywords: Chronic periodontitis; Tissue inhibitor of metalloproteinases; Type 2 diabetes mellitus

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