Neurochem Int. 1987;11(4):389-95. doi: 10.1016/0197-0186(87)90028-3.
Neurochemistry international
R Juszczak, P G Strange
PMID: 20501186 DOI: 10.1016/0197-0186(87)90028-3
Haloperidol coupled to albumin via the hydroxyl or carbonyl group has been used to obtain two classes of monoclonal anti-haloperidol antibodies. Both classes of monoclonal antibody bind haloperidol with high affinity but whereas one class is highly specific for haloperidol the other class binds other butyrophenones e.g. droperidol, spiperone. Anti-idiotypic antisera have been obtained that inhibit [(3)H]haloperidol binding to the anti-haloperidol antibodies but these do not cross react with the D(2) dopamine receptor.