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Kiefer F, Krödel A, Jahn H, et al. Harman and norharman plasma levels in weaned alcoholics: correlations with depression and tobacco smoking. Addict Biol. 2000;5(4):437-41doi: 10.1111/j.1369-1600.2000.tb00213.x.
Kiefer, F., Krödel, A., Jahn, H., Wolf, K., & Barocka, A. (2000). Harman and norharman plasma levels in weaned alcoholics: correlations with depression and tobacco smoking. Addiction biology, 5(4), 437-41. https://doi.org/10.1111/j.1369-1600.2000.tb00213.x
Kiefer, F, et al. "Harman and norharman plasma levels in weaned alcoholics: correlations with depression and tobacco smoking." Addiction biology vol. 5,4 (2000): 437-41. doi: https://doi.org/10.1111/j.1369-1600.2000.tb00213.x
Kiefer F, Krödel A, Jahn H, Wolf K, Barocka A. Harman and norharman plasma levels in weaned alcoholics: correlations with depression and tobacco smoking. Addict Biol. 2000 Oct 01;5(4):437-41. doi: 10.1111/j.1369-1600.2000.tb00213.x. PMID: 20575862.
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Addict Biol. 2000 Oct 01;5(4):437-41. doi: 10.1111/j.1369-1600.2000.tb00213.x.

Harman and norharman plasma levels in weaned alcoholics: correlations with depression and tobacco smoking.

Addiction biology

F Kiefer, A Krödel, H Jahn, K Wolf, A Barocka

Affiliations

  1. Department of Psychiatry, University Hospital Eppendorf, Hamburg, Germany. [email protected]

PMID: 20575862 DOI: 10.1111/j.1369-1600.2000.tb00213.x

Abstract

Based on the hypothesis that β-carbolines are involved in the pathogenesis of alcohol-related mood disturbance, harman and norharman levels were assayed in the blood plasma of alcoholics and correlated to the Hamilton Depression (HAM-D) scores after 3 and 5 weeks post-admission. Tobacco smoking was co-evaluated since it is known to influence β-carboline levels. After a 3-week period, plasma harman but not norharman was increased in depressed alcoholics and positively related to the HAM-D sum-score (r = 0.47; p < 0.04) and to tobacco smoking (r = 0.56; p < 0.02). Since no correlation between depression and smoking was found, these data could account for the higher incidence of depressive symptoms in withdrawn alcoholics with increased harman levels. The partial correlations support this hypothesis.

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