Display options
Cite
Reid JJ, Lieu AT. The effect of 4-week streptozotocin-induced diabetes on responses to endothelin-1 in rat isolated atria. Neurochem Int. 1991;18(4):461-4doi: 10.1016/0197-0186(91)90139-5.
Reid, J. J., & Lieu, A. T. (1991). The effect of 4-week streptozotocin-induced diabetes on responses to endothelin-1 in rat isolated atria. Neurochemistry international, 18(4), 461-4. https://doi.org/10.1016/0197-0186(91)90139-5
Reid, J J, and Lieu, A T. "The effect of 4-week streptozotocin-induced diabetes on responses to endothelin-1 in rat isolated atria." Neurochemistry international vol. 18,4 (1991): 461-4. doi: https://doi.org/10.1016/0197-0186(91)90139-5
Reid JJ, Lieu AT. The effect of 4-week streptozotocin-induced diabetes on responses to endothelin-1 in rat isolated atria. Neurochem Int. 1991;18(4):461-4. doi: 10.1016/0197-0186(91)90139-5. PMID: 20504725.
Copy Download .nbib Format: NLM
Share it on

Neurochem Int. 1991;18(4):461-4. doi: 10.1016/0197-0186(91)90139-5.

The effect of 4-week streptozotocin-induced diabetes on responses to endothelin-1 in rat isolated atria.

Neurochemistry international

J J Reid, A T Lieu

Affiliations

  1. Department of Pharmacology, University of Melbourne, Melbourne, Victoria 3052, Australia.

PMID: 20504725 DOI: 10.1016/0197-0186(91)90139-5

Abstract

The effect of endothelin-1 has been examined on isolated spontaneously beating right atria and electrically driven left atria from diabetic rats and age-matched controls. Diabetes was induced by a single i.v. injection of streptozotocin (65 mg/kg) 4-5 weeks before the experiments. Endothelin-1 (0.01-100 nM) caused concentration-dependent increases in atrial rate and force; the increases were not different between atria from diabetic and control rats. The ability of endothelin-1 to reduce chronotropic and inotropic responses to noradrenaline was also not different between the two groups. Endothelin-1 (10 nM) decreased the chronotropic response to sympathetic nerve stimulation (2 Hz, 10 s) in atria from control rats by 68 +/- 5% (n = 8), but this decrease was slightly smaller (45 +/- 6%, n = 8) in atria from diabetic rats. The results provide no evidence to suggest that the diabetic state markedly alters cardiac responses to endothelin-1.

Publication Types