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Dixit R, Gupta R, Dave L, et al. Clinical profile of patients having pulmonary tuberculosis and renal amyloidosis. Lung India. 2009;26(2):41-5doi: 10.4103/0970-2113.48896.
Dixit, R., Gupta, R., Dave, L., Prasad, N., & Sharma, S. (2009). Clinical profile of patients having pulmonary tuberculosis and renal amyloidosis. Lung India : official organ of Indian Chest Society, 26(2), 41-5. https://doi.org/10.4103/0970-2113.48896
Dixit, Ramakant, et al. "Clinical profile of patients having pulmonary tuberculosis and renal amyloidosis." Lung India : official organ of Indian Chest Society vol. 26,2 (2009): 41-5. doi: https://doi.org/10.4103/0970-2113.48896
Dixit R, Gupta R, Dave L, Prasad N, Sharma S. Clinical profile of patients having pulmonary tuberculosis and renal amyloidosis. Lung India. 2009 Apr;26(2):41-5. doi: 10.4103/0970-2113.48896. PMID: 20440393; PMCID: PMC2860413.
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Lung India. 2009 Apr;26(2):41-5. doi: 10.4103/0970-2113.48896.

Clinical profile of patients having pulmonary tuberculosis and renal amyloidosis.

Lung India : official organ of Indian Chest Society

Ramakant Dixit, Rakesh Gupta, Lokendra Dave, Nishi Prasad, Sidharth Sharma

Affiliations

  1. Department of Pulmonary Medicine, JLN Medical College, Ajmer, India.

PMID: 20440393 PMCID: PMC2860413 DOI: 10.4103/0970-2113.48896

Abstract

OBJECTIVES: This study was planned to define the clinical profile of pulmonary tuberculosis (PTB) patients having renal amyloidosis, to identify the factors responsible for development of amyloidosis, to detect the time period between onset of amyloidosis and PTB, and analyze clinical features of amyloidosis in PTB patients for early diagnosis and timely assessment.

MATERIALS AND METHODS: Patients of PTB having pedal edema, proteinuria, and grossly diseased kidneys on ultrasound abdomen were subjected to renal biopsy and appropriate biochemical investigations. Clinical profile of biopsy proven amyloidosis cases was analyzed.

RESULTS: There were 43 patients (32 males, 11 females, age range 20-65 years) having PTB with pedal edema, proteinuria, and renal medical disease on abdominal ultrasound where amyloidosis was confirmed by renal biopsy. The total duration of illness ranged from two months to seven years (mean 2.25 years) and was less than five years in 93% patients. All patients had significant proteinuria. Nephrotic syndrome was seen in 23, hypertension in 19, hypoalbuminemia in 33, hypercholesterolemia in 29, and deranged renal functions in 32 patients. Ninety percent patients had moderate to far advanced pulmonary lesions on chest radiography with smear positivity in 21 patients.

CONCLUSIONS: Renal amyloidosis is an important complication of PTB and should be suspected clinically in patients presenting with a triad of pedal edema, proteinuria, and medical renal disease on ultrasound. Contrary to general belief, renal amyloidosis may occur in PTB patients having disease for relatively shorter duration, and even if adequately treated.

Keywords: Tuberculosis; amyloidosis; complication; disease duration

References

  1. Nephron. 1995;71(3):367 - PubMed
  2. Indian J Med Sci. 1968 Nov;22(11):770-4 - PubMed
  3. Ann Rheum Dis. 1960 Jun;19:126-34 - PubMed
  4. J Immunol. 1999 Aug 1;163(3):1521-8 - PubMed
  5. Medicine (Baltimore). 1991 Jul;70(4):246-56 - PubMed
  6. Lancet. 2001 Jul 7;358(9275):4-5 - PubMed
  7. Indian J Pathol Bacteriol. 1965 Oct;8(4):285-93 - PubMed
  8. Nefrologia. 2001 Jan-Feb;21(1):88-91 - PubMed
  9. Nephron. 2002;92(3):708-10 - PubMed
  10. Br Med J. 1974 Sep 28;3(5934):795-7 - PubMed
  11. Ann Med Interne (Paris). 1991;142(5):331-4 - PubMed
  12. Postgrad Med J. 1981 Jan;57(663):31-5 - PubMed
  13. Am Rev Respir Dis. 1962 Mar;85:432-5 - PubMed
  14. J Assoc Physicians India. 1990 Jun;38(6):407-10 - PubMed
  15. Eur J Intern Med. 2005 Oct;16(6):437-9 - PubMed
  16. J Indian Med Assoc. 1971 Nov 1;57(9):318-21 - PubMed
  17. Ann Intern Med. 1949 Jul;31(1):105-19 - PubMed
  18. J Struct Biol. 2000 Jun;130(2-3):99-108 - PubMed
  19. J Trop Med Hyg. 1977 Jul;80(7):147-8 - PubMed
  20. Indian J Pathol Microbiol. 1996 Jul;39(3):179-85 - PubMed
  21. Curr Opin Rheumatol. 2001 Jan;13(1):67-73 - PubMed

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