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Przybylski A, Derejko P, Kwaśniewski W, et al. Bleeding complications after pacemaker or cardioverter-defibrillator implantation in patients receiving dual antiplatelet therapy: Results of a prospective, two-centre registry. Neth Heart J. 2010;18(5):230-5doi: 10.1007/BF03091768.
Przybylski, A., Derejko, P., Kwaśniewski, W., Urbańczyk-Swić, D., Zakrzewska, J., Orszulak, W., Orczykowski, M., Filipecki, A., Szumowski, L., Walczak, F., & Trusz-Gluza, M. (2010). Bleeding complications after pacemaker or cardioverter-defibrillator implantation in patients receiving dual antiplatelet therapy: Results of a prospective, two-centre registry. Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 18(5), 230-5. https://doi.org/10.1007/BF03091768
Przybylski, A, et al. "Bleeding complications after pacemaker or cardioverter-defibrillator implantation in patients receiving dual antiplatelet therapy: Results of a prospective, two-centre registry." Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation vol. 18,5 (2010): 230-5. doi: https://doi.org/10.1007/BF03091768
Przybylski A, Derejko P, Kwaśniewski W, Urbańczyk-Swić D, Zakrzewska J, Orszulak W, Orczykowski M, Filipecki A, Szumowski L, Walczak F, Trusz-Gluza M. Bleeding complications after pacemaker or cardioverter-defibrillator implantation in patients receiving dual antiplatelet therapy: Results of a prospective, two-centre registry. Neth Heart J. 2010 May;18(5):230-5. doi: 10.1007/BF03091768. PMID: 20505795; PMCID: PMC2871742.
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Neth Heart J. 2010 May;18(5):230-5. doi: 10.1007/BF03091768.

Bleeding complications after pacemaker or cardioverter-defibrillator implantation in patients receiving dual antiplatelet therapy: Results of a prospective, two-centre registry.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

A Przybylski, P Derejko, W Kwaśniewski, D Urbańczyk-Swić, J Zakrzewska, W Orszulak, M Orczykowski, A Filipecki, L Szumowski, F Walczak, M Trusz-Gluza

Affiliations

  1. Cardiac Arrhythmias Department, Institute of Cardiology, Warsaw, Poland.

PMID: 20505795 PMCID: PMC2871742 DOI: 10.1007/BF03091768

Abstract

Introduction. The aim of the study was to define the prevalence of bleeding events in patients treated with dual antiplatelet therapy (DAT) in comparison with patients receiving only acetylsalicylic acid (ASA).Methods. Prospective two-centre registry of all first implantations of pacemakers, cardioverter-defibrillators and cardiac resynchronisation therapy units in patients receiving ASA (n=194) or DAT (n=53).Results. Bleeding complications were detected in 27 (16.2%) patients in the ASA group and in 13 (24.5%) in the DAT group. There was no significant difference in the overall number of complications between the patients receiving ASA or DAT, although there was a trend towards a higher incidence of overall complication rates in the DAT group (p=0.0637). The incidence of major complications (requiring blood transfusion or surgical intervention or prolonging hospital stay) was low (3.6%), and similar in both groups (3.6 and 3.8% respectively, ns). The rate of minor complications (subcutaneous haematomas) was greater in the DAT group (p=0.015).Conclusions. Treatment with DAT does not increase the risk of major bleeding complications as a result of device implantation; however, minor complications are significantly more frequent. Our results suggest that DAT could be continued in patients undergoing device implantation with a moderate risk of bleeding complications. (Neth Heart J 2010;18:230-5.).

Keywords: Adverse Effects; Defibrillators, Postoperative Complications; Drug Therapy; Pacemaker; Platelet Aggregation Inhibitors

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