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Klein LJ, Visser FC. The effect of insulin on the heart: Part 2: Effects on function during and post myocardial ischaemia. Neth Heart J. 2010;18(5):255-9doi: 10.1007/BF03091772.
Klein, L. J., & Visser, F. C. (2010). The effect of insulin on the heart: Part 2: Effects on function during and post myocardial ischaemia. Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 18(5), 255-9. https://doi.org/10.1007/BF03091772
Klein, L J, and Visser, F C. "The effect of insulin on the heart: Part 2: Effects on function during and post myocardial ischaemia." Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation vol. 18,5 (2010): 255-9. doi: https://doi.org/10.1007/BF03091772
Klein LJ, Visser FC. The effect of insulin on the heart: Part 2: Effects on function during and post myocardial ischaemia. Neth Heart J. 2010 May;18(5):255-9. doi: 10.1007/BF03091772. PMID: 20505799; PMCID: PMC2871746.
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Neth Heart J. 2010 May;18(5):255-9. doi: 10.1007/BF03091772.

The effect of insulin on the heart: Part 2: Effects on function during and post myocardial ischaemia.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

L J Klein, F C Visser

Affiliations

  1. Department of Cardiology, VU Medical Centre, Amsterdam, the Netherlands.

PMID: 20505799 PMCID: PMC2871746 DOI: 10.1007/BF03091772

Abstract

Insulin infusion has been advocated in the treatment of myocardial ischaemia and myocardial infarction. There is evidence from experimental animal studies for a protective effect of high-dose insulin administration in myocardial ischaemia and myocardial infarction. In some relatively small study populations a reduction in mortality was reported in those patients who received glucose-insulin-potassium (GIK) during myocardial infarction, which was confirmed in two meta-analyses. However, it has not been possible to reproduce these positive results in large randomised clinical trials. (Neth Heart J 2010;18:255-9.).

Keywords: Cardiomyopathy; Founder Effect; Mutation; Myosin-binding Protein C

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