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Lee SB, Jung UW, Choi Y, et al. Investigation of bone formation using calcium phosphate glass cement in beagle dogs. J Periodontal Implant Sci. 2010;40(3):125-31doi: 10.5051/jpis.2010.40.3.125.
Lee, S. B., Jung, U. W., Choi, Y., Jamiyandorj, O., Kim, C. S., Lee, Y. K., Chai, J. K., & Choi, S. H. (2010). Investigation of bone formation using calcium phosphate glass cement in beagle dogs. Journal of periodontal & implant science, 40(3), 125-31. https://doi.org/10.5051/jpis.2010.40.3.125
Lee, Seung-Bum, et al. "Investigation of bone formation using calcium phosphate glass cement in beagle dogs." Journal of periodontal & implant science vol. 40,3 (2010): 125-31. doi: https://doi.org/10.5051/jpis.2010.40.3.125
Lee SB, Jung UW, Choi Y, Jamiyandorj O, Kim CS, Lee YK, Chai JK, Choi SH. Investigation of bone formation using calcium phosphate glass cement in beagle dogs. J Periodontal Implant Sci. 2010 Jun;40(3):125-31. doi: 10.5051/jpis.2010.40.3.125. Epub 2010 Jun 25. PMID: 20607057; PMCID: PMC2895518.
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J Periodontal Implant Sci. 2010 Jun;40(3):125-31. doi: 10.5051/jpis.2010.40.3.125. Epub 2010 Jun 25.

Investigation of bone formation using calcium phosphate glass cement in beagle dogs.

Journal of periodontal & implant science

Seung-Bum Lee, Ui-Won Jung, Youna Choi, Otgonbold Jamiyandorj, Chang-Sung Kim, Yong-Keun Lee, Jung-Kiu Chai, Seong-Ho Choi

Affiliations

  1. Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea.

PMID: 20607057 PMCID: PMC2895518 DOI: 10.5051/jpis.2010.40.3.125

Abstract

PURPOSE: Among available biomaterials, bioceramics have drawn special interest due to their bioactivity and the possibility of tailoring their composition. The degradation rate and formulation of bioceramics can be altered to mimic the compositions of the mineral phase of bone. The aim of this study was to investigate the bone formation effect of amorphous calcium phosphate glass cement (CPGC) synthesized by a melting and quenching process.

METHODS: In five male beagle dogs, 4 x 4 mm 1-wall intrabony defects were created bilaterally at the mesial or distal aspect of the mandibular second and fourth premolars. Each of the four defects was divided according to graft materials: CPGC with collagen membrane (CM), biphasic calcium phosphate (BCP) with CM, CM alone, or a surgical flap operation only. The dogs were sacrificed 8 weeks post-surgery, and block sections of the defects were collected for histologic and histometric analysis.

RESULTS: There were significant differences in bone formation and cementum regeneration between the experimental and control groups. In particular, the CPGC and BCP groups showed greater bone formation than the CM and control groups.

CONCLUSIONS: In conclusion, CPGC was replaced rapidly with an abundant volume of new bone; CPGC also contributed slightly to regeneration of the periodontal apparatus.

Keywords: Bone substitutes; Calcium phosphates; Osteogenesis

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