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Pieperhoff S, Barth M, Rickelt S, et al. Desmosomal molecules in and out of adhering junctions: normal and diseased States of epidermal, cardiac and mesenchymally derived cells. Dermatol Res Pract. 2010;2010:139167doi: 10.1155/2010/139167.
Pieperhoff, S., Barth, M., Rickelt, S., & Franke, W. W. (2010). Desmosomal molecules in and out of adhering junctions: normal and diseased States of epidermal, cardiac and mesenchymally derived cells. Dermatology research and practice, 2010139167. https://doi.org/10.1155/2010/139167
Pieperhoff, Sebastian, et al. "Desmosomal molecules in and out of adhering junctions: normal and diseased States of epidermal, cardiac and mesenchymally derived cells." Dermatology research and practice vol. 2010 (2010): 139167. doi: https://doi.org/10.1155/2010/139167
Pieperhoff S, Barth M, Rickelt S, Franke WW. Desmosomal molecules in and out of adhering junctions: normal and diseased States of epidermal, cardiac and mesenchymally derived cells. Dermatol Res Pract. 2010;2010:139167. doi: 10.1155/2010/139167. Epub 2010 Jun 30. PMID: 20671973; PMCID: PMC2909724.
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Dermatol Res Pract. 2010;2010:139167. doi: 10.1155/2010/139167. Epub 2010 Jun 30.

Desmosomal molecules in and out of adhering junctions: normal and diseased States of epidermal, cardiac and mesenchymally derived cells.

Dermatology research and practice

Sebastian Pieperhoff, Mareike Barth, Steffen Rickelt, Werner W Franke

Affiliations

  1. Helmholtz Group for Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

PMID: 20671973 PMCID: PMC2909724 DOI: 10.1155/2010/139167

Abstract

Current cell biology textbooks mention only two kinds of cell-to-cell adhering junctions coated with the cytoplasmic plaques: the desmosomes (maculae adhaerentes), anchoring intermediate-sized filaments (IFs), and the actin microfilament-anchoring adherens junctions (AJs), including both punctate (puncta adhaerentia) and elongate (fasciae adhaerentes) structures. In addition, however, a series of other junction types has been identified and characterized which contain desmosomal molecules but do not fit the definition of desmosomes. Of these special cell-cell junctions containing desmosomal glycoproteins or proteins we review the composite junctions (areae compositae) connecting the cardiomyocytes of mature mammalian hearts and their importance in relation to human arrhythmogenic cardiomyopathies. We also emphasize the various plakophilin-2-positive plaques in AJs (coniunctiones adhaerentes) connecting proliferatively active mesenchymally-derived cells, including interstitial cells of the heart and several soft tissue tumor cell types. Moreover, desmoplakin has also been recognized as a constituent of the plaques of the complexus adhaerentes connecting certain lymphatic endothelial cells. Finally, we emphasize the occurrence of the desmosomal transmembrane glycoprotein, desmoglein Dsg2, out of the context of any junction as dispersed cell surface molecules in certain types of melanoma cells and melanocytes. This broadening of our knowledge on the diversity of AJ structures indicates that it may still be too premature to close the textbook chapters on cell-cell junctions.

References

  1. Am J Hum Genet. 2006 Dec;79(6):1081-8 - PubMed
  2. J Cell Biol. 1963 May;17:375-412 - PubMed
  3. Exp Cell Res. 1983 Jan;143(1):127-42 - PubMed
  4. J Invest Dermatol. 1999 Jul;113(1):22-5 - PubMed
  5. Circ Res. 2006 Sep 15;99(6):646-55 - PubMed
  6. Circ Arrhythm Electrophysiol. 2010 Apr;3(2):126-33 - PubMed
  7. J Cell Biol. 1984 Dec;99(6):2211-5 - PubMed
  8. Neth Heart J. 2007;15(10):348-53 - PubMed
  9. Chin Med J (Engl). 2009 Feb 20;122(4):403-7 - PubMed
  10. Cell Tissue Res. 2009 Jan;335(1):17-25 - PubMed
  11. J Cell Biol. 1996 Nov;135(4):1009-25 - PubMed
  12. Circulation. 2006 Apr 4;113(13):1650-8 - PubMed
  13. Mod Pathol. 2010 Nov;23(11):1429-37 - PubMed
  14. J Cell Biol. 1986 Mar;102(3):1109-17 - PubMed
  15. Cell Tissue Res. 2009 Jan;335(1):97-108 - PubMed
  16. Anat Embryol (Berl). 2001 Sep;204(3):217-24 - PubMed
  17. Annu Rev Med. 2010;61:233-53 - PubMed
  18. Hum Pathol. 1983 Aug;14(8):704-9 - PubMed
  19. Nat Rev Mol Cell Biol. 2004 Apr;5(4):261-70 - PubMed
  20. Heart. 2006 Dec;92(12):1720-3 - PubMed
  21. Microvasc Res. 2001 Jan;61(1):40-8 - PubMed
  22. J Med Genet. 2006 Feb;43(2):e5 - PubMed
  23. Eur J Cell Biol. 2007 Dec;86(11-12):645-55 - PubMed
  24. Cell. 1986 Sep 26;46(7):1063-73 - PubMed
  25. Circulation. 2007 Apr 3;115(13):1710-20 - PubMed
  26. Curr Opin Cardiol. 2006 Jan;21(1):55-63 - PubMed
  27. J Am Coll Cardiol. 2003 Jul 16;42(2):319-27 - PubMed
  28. Differentiation. 1982;23(2):115-27 - PubMed
  29. Circulation. 1970 Jun;41(6):899-912 - PubMed
  30. Mol Biol Cell. 2006 Mar;17(3):1388-98 - PubMed
  31. Curr Opin Cell Biol. 2007 Oct;19(5):515-20 - PubMed
  32. Cell. 1980 Jan;19(1):245-54 - PubMed
  33. Cell Tissue Res. 2009 Oct;338(1):1-17 - PubMed
  34. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7795-800 - PubMed
  35. Circulation. 2006 Jan 24;113(3):356-64 - PubMed
  36. Int J Cancer. 2009 Nov 1;125(9):2036-48 - PubMed
  37. J Anat. 2009 Nov;215(5):536-47 - PubMed
  38. J Cell Mol Med. 2009 Oct;13(10):4219-28 - PubMed
  39. Circ Res. 2009 Sep 11;105(6):523-6 - PubMed
  40. Eur J Cell Biol. 2007 Jul;86(7):377-91 - PubMed
  41. Circulation. 2005 Aug 2;112(5):636-42 - PubMed
  42. J Am Coll Cardiol. 2010 Feb 9;55(6):587-97 - PubMed
  43. Heart Rhythm. 2004 May;1(1):3-11 - PubMed
  44. Heart. 2009 May;95(9):766-73 - PubMed
  45. Eur J Cell Biol. 2010 May;89(5):365-78 - PubMed
  46. Am J Hum Genet. 2007 Nov;81(5):964-73 - PubMed
  47. J Cell Biol. 1998 Dec 28;143(7):2009-22 - PubMed
  48. J Cell Biol. 2010 Feb 22;188(4):463-71 - PubMed
  49. J Cell Biol. 1996 Oct;135(1):215-25 - PubMed
  50. J Cell Biol. 2004 Oct 11;167(1):149-60 - PubMed
  51. Biochim Biophys Acta. 2007 Jan;1773(1):69-77 - PubMed
  52. Heart Rhythm. 2010 Jan;7(1):22-9 - PubMed
  53. Am J Hum Genet. 2006 Nov;79(5):978-84 - PubMed
  54. Ann N Y Acad Sci. 1985;455:213-40 - PubMed
  55. J Cell Sci. 2007 Jun 15;120(Pt 12):2126-36 - PubMed
  56. Hum Mutat. 2006 Nov;27(11):1157 - PubMed
  57. Hum Mol Genet. 2000 Nov 1;9(18):2761-6 - PubMed
  58. Circulation. 2006 Apr 4;113(13):1641-9 - PubMed
  59. J Cell Sci. 1999 Jul;112 ( Pt 14):2265-76 - PubMed
  60. Cell Tissue Res. 2008 Dec;334(3):401-22 - PubMed
  61. Circ Res. 2010 Mar 19;106(5):880-90 - PubMed
  62. Circ Cardiovasc Genet. 2009 Oct;2(5):428-35 - PubMed
  63. Circ J. 2006 Jul;70(7):933-5 - PubMed
  64. J Invest Dermatol. 2006 Jul;126(7):1651-4 - PubMed
  65. Eur J Cell Biol. 2006 Feb;85(2):69-82 - PubMed
  66. Circ Cardiovasc Genet. 2009 Oct;2(5):418-27 - PubMed
  67. J Cell Sci. 1998 Oct;111 ( Pt 20):3045-57 - PubMed
  68. J Invest Dermatol. 2010 Apr;130(4):968-78 - PubMed
  69. Dev Biol. 2006 Jan 15;289(2):430-41 - PubMed
  70. Differentiation. 1981;20(3):217-41 - PubMed
  71. J Cell Sci. 1996 Aug;109 ( Pt 8):2141-9 - PubMed
  72. Eur J Cell Biol. 2006 Jun;85(6):469-85 - PubMed
  73. Curr Opin Cell Biol. 1997 Oct;9(5):674-82 - PubMed
  74. Am J Cardiol. 2009 May 15;103(10):1439-44 - PubMed
  75. Eur Heart J. 2005 Aug;26(16):1666-75 - PubMed
  76. Exp Cell Res. 1999 Aug 1;250(2):452-64 - PubMed
  77. Cell Tissue Res. 2006 Apr;324(1):55-67 - PubMed
  78. Curr Opin Cell Biol. 2004 Oct;16(5):536-43 - PubMed
  79. J Cell Biol. 1988 May;106(5):1679-91 - PubMed
  80. Cell Tissue Res. 2009 Jan;335(1):109-41 - PubMed
  81. Int J Cardiol. 2008 May 7;126(1):92-100 - PubMed
  82. J Cell Sci. 1984 Aug;70:41-60 - PubMed
  83. BMC Med Genet. 2007 Oct 26;8:65 - PubMed
  84. J Formos Med Assoc. 2008 Jul;107(7):548-58 - PubMed
  85. Nat Clin Pract Cardiovasc Med. 2008 May;5(5):258-67 - PubMed
  86. Eur J Cell Biol. 2002 Aug;81(8):419-35 - PubMed
  87. Differentiation. 1999 Jun;64(5):291-306 - PubMed
  88. Heart Rhythm. 2007 Sep;4(9):1196-205 - PubMed
  89. Heart Rhythm. 2006 Aug;3(8):939-44 - PubMed
  90. J Am Acad Dermatol. 2003 Feb;48(2):244-52 - PubMed
  91. Differentiation. 1994 Aug;57(2):97-117 - PubMed
  92. Cell Tissue Res. 2009 Jul;337(1):63-77 - PubMed
  93. J Cardiovasc Electrophysiol. 2008 Nov;19(11):1212-4 - PubMed
  94. Cardiology. 2009;113(1):28-34 - PubMed
  95. J Invest Dermatol. 2007 Sep;127(9):2191-206 - PubMed
  96. J Cell Biol. 1997 Jul 14;138(1):193-201 - PubMed
  97. Heart Rhythm. 2009 Aug;6(8 Suppl):S62-5 - PubMed
  98. Cell Commun Adhes. 2009;16(1-3):15-27 - PubMed
  99. Biochim Biophys Acta. 2008 Mar;1778(3):572-87 - PubMed
  100. Br J Dermatol. 2010 Jun;162(6):1388-94 - PubMed
  101. Eur Heart J. 2007 Mar;28(5):581-8 - PubMed
  102. Eur Heart J. 2006 Sep;27(18):2208-16 - PubMed
  103. Eur J Immunol. 2008 Aug;38(8):2142-55 - PubMed
  104. Histochem Cell Biol. 2008 Jul;130(1):21-54 - PubMed
  105. Heart Rhythm. 2008 Dec;5(12):1715-23 - PubMed
  106. J Cardiovasc Electrophysiol. 2005 Aug;16(8):927-35 - PubMed
  107. J Am Coll Cardiol. 2001 Nov 1;38(5):1477-84 - PubMed
  108. J Exp Med. 2007 Oct 1;204(10):2349-62 - PubMed
  109. Eur J Cell Biol. 2008 Jul;87(7):399-411 - PubMed
  110. Heart Rhythm. 2008 Dec;5(12):1724-5 - PubMed
  111. J Cell Biol. 1995 Nov;131(3):745-60 - PubMed
  112. Cell Tissue Res. 2009 Jan;335(1):49-65 - PubMed
  113. Exp Cell Res. 2003 Apr 15;285(1):114-30 - PubMed
  114. N Engl J Med. 2009 Mar 12;360(11):1075-84 - PubMed
  115. Nat Genet. 2004 Nov;36(11):1162-4 - PubMed
  116. Circulation. 2006 Mar 7;113(9):1171-9 - PubMed
  117. J Clin Invest. 1999 Feb;103(4):461-8 - PubMed
  118. Cell Tissue Res. 1997 Dec;290(3):481-99 - PubMed
  119. Clin Res Cardiol. 2009 Mar;98(3):141-58 - PubMed
  120. J Cell Biol. 1978 Nov;79(2 Pt 1):427-43 - PubMed
  121. Lancet. 2000 Jun 17;355(9221):2119-24 - PubMed
  122. J Clin Invest. 2006 Jul;116(7):2012-21 - PubMed
  123. Card Electrophysiol Rev. 2002 Feb;6(1-2):72-80 - PubMed
  124. Circ Res. 2007 Sep 28;101(7):703-11 - PubMed
  125. Differentiation. 2009 Apr;77(4):360-8 - PubMed
  126. Differentiation. 1994 Dec;58(2):113-31 - PubMed
  127. Eur J Cell Biol. 2008 Jul;87(7):413-30 - PubMed
  128. Development. 2001 Mar;128(6):929-41 - PubMed

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