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Stefanidou M, Georgiou M, Maravelias C, et al. The effects of morphine, cocaine, amphetamine and hashish on the phagocytosis of the protozoon Tetrahymena pyriformis strain W. Toxicol In Vitro. 1990;4(6):779-81doi: 10.1016/0887-2333(90)90048-x.
Stefanidou, M., Georgiou, M., Maravelias, C., & Koutselinis, A. (1990). The effects of morphine, cocaine, amphetamine and hashish on the phagocytosis of the protozoon Tetrahymena pyriformis strain W. Toxicology in vitro : an international journal published in association with BIBRA, 4(6), 779-81. https://doi.org/10.1016/0887-2333(90)90048-x
Stefanidou, M, et al. "The effects of morphine, cocaine, amphetamine and hashish on the phagocytosis of the protozoon Tetrahymena pyriformis strain W." Toxicology in vitro : an international journal published in association with BIBRA vol. 4,6 (1990): 779-81. doi: https://doi.org/10.1016/0887-2333(90)90048-x
Stefanidou M, Georgiou M, Maravelias C, Koutselinis A. The effects of morphine, cocaine, amphetamine and hashish on the phagocytosis of the protozoon Tetrahymena pyriformis strain W. Toxicol In Vitro. 1990;4(6):779-81. doi: 10.1016/0887-2333(90)90048-x. PMID: 20702165.
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Toxicol In Vitro. 1990;4(6):779-81. doi: 10.1016/0887-2333(90)90048-x.

The effects of morphine, cocaine, amphetamine and hashish on the phagocytosis of the protozoon Tetrahymena pyriformis strain W.

Toxicology in vitro : an international journal published in association with BIBRA

M Stefanidou, M Georgiou, C Maravelias, A Koutselinis

Affiliations

  1. Department of Forensic Medicine and Toxicology, University of Athens, Medical School, Goudi, Mikras Asias Str, Athens 115 27, Greece.

PMID: 20702165 DOI: 10.1016/0887-2333(90)90048-x

Abstract

Cells of the ciliated protozoon Tetrahymena pyriformis, strain W, grown in a peptone-yeast medium usually contain many phagocytic vacuoles. The phagocytic activity of this protozoon was studied in vivo using heat-killed yeast stained with carmine dye and after exposing the cultures for 2 hr to morphine (20 mug/ml), cocaine (20 mug/ml), amphetamine (0.5 mug/ml) or hashish (0.1 mug/ml). The number of vacuoles formed indicated the phagocytic activity after treatment with the drugs of abuse. Amphetamine caused a slight increase (P < 0.05) in the phagocytic activity of the protozoon, whereas morphine, cocaine and hashish each caused a significant (P < 0.01) decrease in this activity.

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