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Patil NT, Kavthe RD, Raut VS, et al. Platinum-catalyzed formal Markownikoff's hydroamination/hydroarylation cascade of terminal alkynes assisted by tethered hydroxyl groups. J Org Chem. 2009;74(16):6315-8doi: 10.1021/jo901200j.
Patil, N. T., Kavthe, R. D., Raut, V. S., & Reddy, V. V. (2009). Platinum-catalyzed formal Markownikoff's hydroamination/hydroarylation cascade of terminal alkynes assisted by tethered hydroxyl groups. The Journal of organic chemistry, 74(16), 6315-8. https://doi.org/10.1021/jo901200j
Patil, Nitin T, et al. "Platinum-catalyzed formal Markownikoff's hydroamination/hydroarylation cascade of terminal alkynes assisted by tethered hydroxyl groups." The Journal of organic chemistry vol. 74,16 (2009): 6315-8. doi: https://doi.org/10.1021/jo901200j
Patil NT, Kavthe RD, Raut VS, Reddy VV. Platinum-catalyzed formal Markownikoff's hydroamination/hydroarylation cascade of terminal alkynes assisted by tethered hydroxyl groups. J Org Chem. 2009 Aug 21;74(16):6315-8. doi: 10.1021/jo901200j. PMID: 20560573.
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J Org Chem. 2009 Aug 21;74(16):6315-8. doi: 10.1021/jo901200j.

Platinum-catalyzed formal Markownikoff's hydroamination/hydroarylation cascade of terminal alkynes assisted by tethered hydroxyl groups.

The Journal of organic chemistry

Nitin T Patil, Rahul D Kavthe, Vivek S Raut, Vaddu V N Reddy

Affiliations

  1. Organic Chemistry Division II, Indian Institute of Chemical Technology, Hyderabad 500 607, India. [email protected]

PMID: 20560573 DOI: 10.1021/jo901200j

Abstract

An efficient method for Markownikoff's hydroamination-hydroarylation of alkynols using PtBr(2) as catalyst has been developed. The platinum-catalyzed reactions of alkynols with amino group containing aromatics were achieved in methanol over a reaction time of 6-24 h and temperature ranging from rt to 80 degrees C. This method works well for a variety of alkynols and aromatic amino compounds to give substituted pyrrolo[1,2-a]quinoxalines and indolo[3,2-c]quinolines in good to excellent yields.

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