Semin Plast Surg. 2007 Nov;21(4):242-9. doi: 10.1055/s-2007-991194.

Experience with nerve allograft transplantation.

Seminars in plastic surgery

Ida K Fox, Susan E Mackinnon

PMID: 20567677 PMCID: PMC2884844 DOI: 10.1055/s-2007-991194

Abstract

Nerve allograft transplantation should be used for the repair of devastating peripheral nerve injuries that cannot be reconstructed through traditional means such as autologous nerve grafting or nerve transfer procedures. The risks of required systemic immunosuppression, although only temporary for nerve allograft recipients, preclude widespread use of this treatment modality. Translational research has led to several advancements in this field including the use of preoperative allograft cold preservation in University of Wisconsin organ preservation solution and inclusion of tacrolimus as part of the immunosuppressive regimen. Investigation of how to further diminish nerve allograft immunogenicity, speed neuroregeneration by use of agents such as tacrolimus, and promote preferential motor regeneration will further advance this field with the goal of restoring optimal function while minimizing patient morbidity.

Keywords: Peripheral nerve; allograft; transplantation

References

1. Muscle Nerve. 1998 Nov;21(11):1507-22 - PubMed
2. J Pharmacol Exp Ther. 1997 Aug;282(2):1084-93 - PubMed
3. Neurosci Lett. 1999 May 21;267(1):33-6 - PubMed
4. Transplant Proc. 1998 Sep;30(6):2721-3 - PubMed
5. Plast Reconstr Surg. 1999 Jul;104(1):152-60 - PubMed
6. Laryngoscope. 2001 Mar;111(3):439-47 - PubMed
7. Muscle Nerve. 2000 Aug;23(8):1227-33 - PubMed
8. Tissue Eng. 2003 Apr;9(2):209-18 - PubMed
9. J Neuroimmunol. 1995 Jan;56(1):9-16 - PubMed
10. Neurosurgery. 1982 Jan;10(1):61-9 - PubMed
11. J Hand Surg Br. 1999 Feb;24(1):38-42 - PubMed
12. Plast Reconstr Surg. 2001 May;107(6):1419-29 - PubMed
13. Exp Neurol. 2004 Mar;186(1):59-69 - PubMed
14. Muscle Nerve. 2000 Apr;23(4):633-40 - PubMed
15. Neurosurgery. 1984 Nov;15(5):690-3 - PubMed
16. Surg Gynecol Obstet. 1971 May;132(5):839-45 - PubMed
17. J Pharmacol Exp Ther. 1999 Jun;289(3):1202-10 - PubMed
18. J Neurol Sci. 1990 Apr;96(1):75-88 - PubMed
19. J Neurosci. 1994 Mar;14(3 Pt 1):1309-19 - PubMed
20. J Neurosci Methods. 2004 Apr 30;134(2):133-40 - PubMed
21. Neurosurgery. 2006 Oct;59(4):740-7; discussion 747-8 - PubMed
22. Plast Reconstr Surg. 2003 Dec;112(7):1832-40 - PubMed
23. Transplantation. 1996 Dec 15;62(11):1643-9 - PubMed
24. Ann N Y Acad Sci. 1988;540:472-4 - PubMed
25. Int Surg. 2002 Oct-Dec;87(4):274-8 - PubMed
26. Zh Vopr Neirokhir Im N N Burdenko. 1990 Nov-Dec;(6):8-10 - PubMed
27. Microsurgery. 2005;25(1):61-70 - PubMed
28. J Surg Res. 1990 Sep;49(3):233-8 - PubMed
29. Transplantation. 2005 May 15;79(9):1210-4 - PubMed
30. Plast Reconstr Surg. 1996 Jan;97(1):152-60 - PubMed
31. Surgery. 1998 Aug;124(2):448-56 - PubMed
32. Laryngoscope. 2006 Sep;116(9):1685-92 - PubMed
33. Muscle Nerve. 2002 Sep;26(3):348-55 - PubMed
34. J Reconstr Microsurg. 2006 May;22(4):245-54 - PubMed
35. Biomaterials. 2003 Jun;24(13):2405-12 - PubMed
36. Microsurgery. 2006;26(8):599-607 - PubMed
37. Exp Neurol. 2004 Dec;190(2):347-55 - PubMed
38. Lancet. 1972 Mar 25;1(7752):647-50 - PubMed
39. J Reconstr Microsurg. 2003 May;19(4):241-8 - PubMed
40. Nat Med. 1997 Apr;3(4):421-8 - PubMed
41. Hand Clin. 2000 Feb;16(1):105-22 - PubMed
42. Neurol Res. 2004 Mar;26(2):161-6 - PubMed
43. Clin Plast Surg. 2005 Oct;32(4):605-16, viii - PubMed
44. J Bone Joint Surg Am. 2002 Oct;84(10):1861-70 - PubMed
45. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3191-5 - PubMed
46. Muscle Nerve. 1995 Oct;18(10):1128-38 - PubMed
47. J Neurosurg. 1980 Apr;52(4):557-63 - PubMed
48. Exp Neurol. 2003 Sep;183(1):220-31 - PubMed
49. Am J Transplant. 2005 Jun;5(6):1580-1 - PubMed
50. J Hand Surg Am. 2005 Sep;30(5):986-9 - PubMed
51. Transplantation. 1989 Sep;48(3):386-92 - PubMed
52. Plast Reconstr Surg. 2001 Feb;107(2):485-94; discussion 495-6 - PubMed
53. Tissue Eng. 2000 Apr;6(2):129-38 - PubMed
54. J Reconstr Microsurg. 1999 May;15(4):307-11 - PubMed
55. Exp Neurol. 1987 Aug;97(2):289-300 - PubMed
56. Am J Med Sci. 1997 May;313(5):257-63 - PubMed
57. J Neurosci. 1993 Jun;13(6):2730-8 - PubMed
58. Ann Pharmacother. 1994 Apr;28(4):501-11 - PubMed
59. Plast Reconstr Surg. 2005 Mar;115(3):31e-35e; discussion 36e-37e - PubMed
60. Plast Reconstr Surg. 2007 Jan;119(1):246-259 - PubMed
61. J Neurosci. 1988 Mar;8(3):1026-31 - PubMed
62. J Hand Surg Am. 1991 Mar;16(2):227-9 - PubMed
63. Transplantation. 1997 May 15;63(9):1210-5 - PubMed
64. Hand. 1972 Feb;4(1):79-84 - PubMed
65. Microsurgery. 2001;21(3):96-101 - PubMed
66. Transplantation. 1993 Jul;56(1):154-62 - PubMed
67. J Reconstr Microsurg. 1993 Sep;9(5):367-72 - PubMed
68. Plast Reconstr Surg. 1992 Oct;90(4):695-9 - PubMed
69. Neuroreport. 2001 Jun 13;12(8):1719-22 - PubMed
70. J Reconstr Microsurg. 2003 Jul;19(5):299-302 - PubMed
71. J Reconstr Microsurg. 1999 Apr;15(3):183-90 - PubMed
72. J Neurosurg. 1996 Apr;84(4):671-6 - PubMed
73. Plast Reconstr Surg. 2005 Mar;115(3):823-30 - PubMed
74. Acta Haematol. 1998;99(3):171-4 - PubMed
75. Clin Transplant. 1999 Jun;13(3):209-20 - PubMed
76. J Comp Neurol. 1993 May 1;331(1):134-47 - PubMed
77. Plast Reconstr Surg. 2004 Dec;114(7):1802-14; discussion 1815-7 - PubMed
78. Plast Reconstr Surg. 1985 Mar;75(3):384-8 - PubMed
79. Restor Neurol Neurosci. 2000;17(1):39-44 - PubMed
80. JAMA. 1997 Dec 10;278(22):1993-9 - PubMed
81. Neuroscience. 2006 Jun 19;140(1):101-10 - PubMed
82. Curr Opin Immunol. 1989-1990;2(6):864-9 - PubMed
83. Microsurgery. 2002;22(7):311-5 - PubMed
84. Restor Neurol Neurosci. 1994 Jan 1;6(4):287-96 - PubMed
85. Plast Reconstr Surg. 1999 Jun;103(7):1928-36 - PubMed
86. Clin Plast Surg. 2003 Oct;30(4):559-63, viii - PubMed
87. Glia. 1994 Feb;10(2):121-31 - PubMed

Publication Types

• Journal Article