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Zhang J, Feng K, Cuddihy M, et al. Spontaneous formation of temperature-responsive assemblies by molecular recognition of a β-cyclodextrin containing block copolymer and poly(N-isopropylacrylamide). Soft Matter. 2010;6(15):3669-3679doi: 10.1039/c000898b.
Zhang, J., Feng, K., Cuddihy, M., Kotov, N. A., & Ma, P. X. (2010). Spontaneous formation of temperature-responsive assemblies by molecular recognition of a β-cyclodextrin containing block copolymer and poly(N-isopropylacrylamide). Soft matter, 6(15), 3669-3679. https://doi.org/10.1039/c000898b
Zhang, Jianxiang, et al. "Spontaneous formation of temperature-responsive assemblies by molecular recognition of a β-cyclodextrin containing block copolymer and poly(N-isopropylacrylamide)." Soft matter vol. 6,15 (2010): 3669-3679. doi: https://doi.org/10.1039/c000898b
Zhang J, Feng K, Cuddihy M, Kotov NA, Ma PX. Spontaneous formation of temperature-responsive assemblies by molecular recognition of a β-cyclodextrin containing block copolymer and poly(N-isopropylacrylamide). Soft Matter. 2010 Aug 07;6(15):3669-3679. doi: 10.1039/c000898b. PMID: 20657806; PMCID: PMC2907537.
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Soft Matter. 2010 Aug 07;6(15):3669-3679. doi: 10.1039/c000898b.

Spontaneous formation of temperature-responsive assemblies by molecular recognition of a β-cyclodextrin containing block copolymer and poly(N-isopropylacrylamide).

Soft matter

Jianxiang Zhang, Kai Feng, Meghan Cuddihy, Nicholas A Kotov, Peter X Ma

Affiliations

  1. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.

PMID: 20657806 PMCID: PMC2907537 DOI: 10.1039/c000898b

Abstract

We report the construction of novel temperature-responsive assemblies based on a double hydrophilic block copolymer (consisting of a PEG block and a β-cyclodextrin-containing block, PEG-b-PCD) and poly(N-isopropylacrylamide) (PNIPAm). Thus formed nano-assemblies exhibit a spherical morphology and have a temperature-responsive loose core. The driving force for the formation of these assemblies was found to be the inclusion complexation interaction between the hydrophobic cavity of β-cyclodextrin and the isopropyl group of PNIPAm. The particle size of these assemblies changed reversibly in response to the external temperature change. The particle size also changed with the PNIPAm/PEG-b-PCD weight ratio. A model hydrophobic drug (indomethacin) was loaded into these assemblies with a high efficiency. An in vitro release study showed that the payload could be released in a sustained manner after an initial burst release. The release rate could be switched between high and low in an ON/OFF fashion by temperature. These results demonstrate that the nano-assemblies have high potential for applications in controlled drug delivery and biomedicine when temperature responsiveness is desired.

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