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Koh EJ, Kim HN, Ma TZ, et al. Comparative analysis of serum proteomes of moyamoya disease and normal controls. J Korean Neurosurg Soc. 2010;48(1):8-13doi: 10.3340/jkns.2010.48.1.8.
Koh, E. J., Kim, H. N., Ma, T. Z., Choi, H. Y., & Kwak, Y. G. (2010). Comparative analysis of serum proteomes of moyamoya disease and normal controls. Journal of Korean Neurosurgical Society, 48(1), 8-13. https://doi.org/10.3340/jkns.2010.48.1.8
Koh, Eun-Jeong, et al. "Comparative analysis of serum proteomes of moyamoya disease and normal controls." Journal of Korean Neurosurgical Society vol. 48,1 (2010): 8-13. doi: https://doi.org/10.3340/jkns.2010.48.1.8
Koh EJ, Kim HN, Ma TZ, Choi HY, Kwak YG. Comparative analysis of serum proteomes of moyamoya disease and normal controls. J Korean Neurosurg Soc. 2010 Jul;48(1):8-13. doi: 10.3340/jkns.2010.48.1.8. Epub 2010 Jul 31. PMID: 20717506; PMCID: PMC2916155.
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J Korean Neurosurg Soc. 2010 Jul;48(1):8-13. doi: 10.3340/jkns.2010.48.1.8. Epub 2010 Jul 31.

Comparative analysis of serum proteomes of moyamoya disease and normal controls.

Journal of Korean Neurosurgical Society

Eun-Jeong Koh, Han-Na Kim, Tian-Ze Ma, Ha-Young Choi, Yong-Geun Kwak

Affiliations

  1. Department of Neurosurgery, Chonbuk National University Medical School, Jeonju, Korea.

PMID: 20717506 PMCID: PMC2916155 DOI: 10.3340/jkns.2010.48.1.8

Abstract

OBJECTIVE: The etiology and pathogenesis of moyamoya disease remain unclear. Furthermore, the definitive diagnostic protein-biomarkers for moyamoya disease are still unknown. The present study analyzed serum proteomes from normal controls and moyamoya patients to identify novel serological biomarkers for diagnosing moyamoya disease.

METHODS: We compared the two-dimensional electrophoresis patterns of sera from moyamoya disease patients and normal controls and identified the differentially-expressed spots by matrix-assisted laser desorption/ionization-time-of flight mass spectrometry and electrospray ionization quadruple time-of-flight mass spectrometry.

RESULTS: We found and analyzed 22 differently-expressed proteomes. Two proteins were up-regulated. Twenty proteins were down-regulated. Complement C1 inhibitor protein and apolipoprotein C-III showed predominantly changed expressions (complement C1 inhibitor protein averaged a 7.23-fold expression in moyamoya patients as compared to controls, while apolipoprotein C-III averaged a 0.066-fold expression).

CONCLUSION: Although our study had a small sample size, our proteomic data provide serologic clue proteins for understanding moyamoya disease.

Keywords: Moyamoya disease; Proteome

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